| pubmed-article:8885870 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8885870 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:8885870 | lifeskim:mentions | umls-concept:C1335193 | lld:lifeskim |
| pubmed-article:8885870 | lifeskim:mentions | umls-concept:C0035143 | lld:lifeskim |
| pubmed-article:8885870 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:8885870 | lifeskim:mentions | umls-concept:C0021027 | lld:lifeskim |
| pubmed-article:8885870 | lifeskim:mentions | umls-concept:C1416161 | lld:lifeskim |
| pubmed-article:8885870 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:8885870 | lifeskim:mentions | umls-concept:C1301676 | lld:lifeskim |
| pubmed-article:8885870 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:8885870 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8885870 | pubmed:dateCreated | 1996-12-4 | lld:pubmed |
| pubmed-article:8885870 | pubmed:abstractText | Cytokine regulation of B cell development was analyzed using interleukin-2 (IL-2)-induced transcription of the J chain gene as a model system. A nuclear target of the IL-2 signal was identified as the Pax5 transcription factor, BSAP, which recognizes a negative regulatory motif in the J chain promoter. Functional assays showed that BSAP mediates the silencing of the J chain gene during the early stages of B cell development, but repression is relieved during the antigen-driven stages in a concentration-dependent manner by an IL-2-induced down-regulation of BSAP RNA expression. At the low levels present in J chain-expressing plasma cells, BSAP repression could be overridden by positive-acting factors binding to down-stream J chain promoter elements. Overexpression of BSAP in these cells reversed the positive regulation and inhibited J chain gene transcription. Thus, IL-2 regulation of BSAP concentration may provide a mechanism for controlling both repressor and activator functions of BSAP during a B cell immune response. | lld:pubmed |
| pubmed-article:8885870 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8885870 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8885870 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8885870 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8885870 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8885870 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8885870 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8885870 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:8885870 | pubmed:author | pubmed-author:KoshlandM EME | lld:pubmed |
| pubmed-article:8885870 | pubmed:author | pubmed-author:JohnsonK WKW | lld:pubmed |
| pubmed-article:8885870 | pubmed:author | pubmed-author:RinkenbergerJ... | lld:pubmed |
| pubmed-article:8885870 | pubmed:author | pubmed-author:WallinJ JJJ | lld:pubmed |
| pubmed-article:8885870 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8885870 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:8885870 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8885870 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8885870 | pubmed:pagination | 377-86 | lld:pubmed |
| pubmed-article:8885870 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:8885870 | pubmed:meshHeading | pubmed-meshheading:8885870-... | lld:pubmed |
| pubmed-article:8885870 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8885870 | pubmed:articleTitle | An interleukin-2 signal relieves BSAP (Pax5)-mediated repression of the immunoglobulin J chain gene. | lld:pubmed |
| pubmed-article:8885870 | pubmed:affiliation | Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA. | lld:pubmed |
| pubmed-article:8885870 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8885870 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8885870 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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