Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1997-1-24
|
| pubmed:abstractText |
Debate continues on the efficacy and safety of intravaginal nonoxynol-9 for the prevention of horizontal transmission of human immunodeficiency and other sexually transmitted diseases. Little attention has been paid to the effects of nonoxynol-9 contained in the lubricant of many condoms.
|
| pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Barrier Methods,
http://linkedlifedata.com/resource/pubmed/keyword/Behavior,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Condom,
http://linkedlifedata.com/resource/pubmed/keyword/Contraception,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Methods,
http://linkedlifedata.com/resource/pubmed/keyword/Dermatological Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Developed Countries,
http://linkedlifedata.com/resource/pubmed/keyword/England,
http://linkedlifedata.com/resource/pubmed/keyword/Europe,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Nonoxynol-9--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Northern Europe,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Prostitutes--women,
http://linkedlifedata.com/resource/pubmed/keyword/Research Report,
http://linkedlifedata.com/resource/pubmed/keyword/Sex Behavior,
http://linkedlifedata.com/resource/pubmed/keyword/Spermicidal Contraceptive...,
http://linkedlifedata.com/resource/pubmed/keyword/United Kingdom
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0148-5717
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
23
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
413-4
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:otherAbstract |
PIP: It remains unclear whether the intravaginal application of nonoxynol-9 (N-9) safely prevents the transmission of HIV and other sexually transmitted diseases (STDs) during sexual intercourse. Some studies have suggested a protective effect, while others a potential adverse effect created through the inflammation and ulceration of the genital tract caused by N-9. N-9 is commonly found in the lubricating agents used on condoms. However, the dose in each condom is small relative to pessaries or spermicidal gels. 70 female prostitutes participated in a study to assess the tolerability of different levels of N-9 in condom lubricants. Women were excluded from participation if they had a STD, vaginal candidiasis or bacterial vaginosis, were pregnant, or were using intravaginal spermicides for contraception. Participants were asked to use the trial condoms for all vaginal intercourse for a 2-week period and to avoid using any other spermicidal preparation. 1636 identical condoms were used during the study, either lubricated with polyethyleneglycol, polyethyleneglycol with 2% N-9, or polyethyleneglycol with 4% N-9. No association was found between the dose of N-9 and reported symptoms or signs of genital tract inflammation, although an increased dose of N-9 was associated with increased numbers of polymorphonuclear leukocytes on a vaginal wall smear. Future studies of the effects of low-dose N-9 on the female genital tract require highly controlled exposures together with colposcopy with or without vaginal biopsy for confirmation.
|
| pubmed:meshHeading |
pubmed-meshheading:8885074-Condoms,
pubmed-meshheading:8885074-Double-Blind Method,
pubmed-meshheading:8885074-Female,
pubmed-meshheading:8885074-Humans,
pubmed-meshheading:8885074-Lubrication,
pubmed-meshheading:8885074-Neutrophils,
pubmed-meshheading:8885074-Nonoxynol,
pubmed-meshheading:8885074-Pilot Projects,
pubmed-meshheading:8885074-Prostitution,
pubmed-meshheading:8885074-Spermatocidal Agents,
pubmed-meshheading:8885074-Vaginal Smears,
pubmed-meshheading:8885074-Vaginitis
|
| pubmed:articleTitle |
Nonoxynol-9 in lubricated condoms. Results of a study in female prostitutes.
|
| pubmed:affiliation |
Department of Epidemiology and Public Health, Imperial College of Science, Technology and Medicine, London, United Kingdom.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|