Linked Life Data

8884943

Source:http://linkedlifedata.com/resource/pubmed/id/8884943

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1997-2-5
pubmed:abstractText
Given the conspicuous association between aggressive antisocial traits and alcoholism in men, we investigated whether or not a link between defensive aggressive behavior and homecage alcohol consumption could be demonstrated in the laboratory rat. This was accomplished by observing ethanol intake and hyperreactivity towards the experimenter in rats made hyperdefensive by brain lesions. Rats with medial hypothalamic electrocoagulations showed a remarkable degree of hyperdefensiveness, lasting throughout the entire 6-week postoperative period. Alcohol intake, on the other hand, was not different from sham-operated controls when the beverage was offered as a plain 6% solution or in a 0.2% saccharin vehicle. When subjected to the stress of food restriction, which enhances ethanol intake in normal rats, medial hypothalamic subjects actually decreased their alcohol consumption. Electrolytic lesions in the dorsal and median raphe brought about a transient increase in defensive aggression, but no alteration in ethanol drinking. Animals with ibotenic acid-induced extensive lesions to the ventral striatum and septal area were not only viciously aggressive, but also drank considerably more alcohol than controls. Ibotenic acid-lesioned rats did not respond to the saccharin or food-restriction conditions by increasing their alcohol intake further, perhaps because they drank at a maximal rate already during the plain ethanol-phase of the experiment. These observations show that basal forebrain dysfunction in the rat can give rise to excessive alcohol intake and heightened aggression, a constellation of behavioral symptoms observed in male type 2 alcoholics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0031-9384
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1125-35
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
An animal model for type 2 alcoholism? Alcohol consumption and aggressive behavior following lesions in the raphe nuclei, medial hypothalamus, or ventral striatum-septal area.
pubmed:affiliation
Department of Psychology, Göteborg University, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't