Linked Life Data

8884697

Source:http://linkedlifedata.com/resource/pubmed/id/8884697

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1997-2-7
pubmed:abstractText
Optimization of antihypertensive drug therapy continues to be a clinical challenge in patients with diabetes mellitus and its complications. We assessed the interference of autonomic neuropathy with drug effects on heart rate variability in 13 hypertensive diabetic subjects (mean age 48.4 years) during treatment with two blood pressure lowering drugs, metoprolol and enalapril. The baseline findings were compared with those obtained in 24 diabetic subjects without hypertension (mean age 32.5 years) and in 24 non-diabetic hypertensive patients (mean age 47.6 years). Cardiovagal autonomic neuropathy was present in 10/13 (77%) of the hypertensive diabetic group, 14/24 (58%) the non-hypertensive diabetic group and 17/24 (71%) the non-diabetic hypertensive group. Heart rate variation was studied by power spectral analysis using total variability and three different frequency bands (low-frequency 0.025-0.075 Hz, mid-frequency 0.075-0.15 Hz and high-frequency 0.15-0.40 Hz). At baseline, the two hypertensive groups showed significantly smaller mid- and high-frequency heart rate variability compared with the diabetes only group. Age and the presence of cardiovagal autonomic neuropathy were important determinants of variability. Both metoprolol and enalapril reduced blood pressure comparably in hypertensive diabetics while metoprolol also reduced heart rate. Metoprolol decreased heart rate variability at the low-frequency and mid-frequency bands even after correction for the change in heart rate. Heart rate variability was not significantly altered by enalapril. In subjects with hypertension, diabetes and autonomic neuropathy, metoprolol almost abolished all heart rate variability. Therefore, an ACE inhibitor is a more neutral treatment alternative in such patients from the point of view of autonomic cardiac control.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0165-1838
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
61-70
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Antihypertensive treatment and heart rate variability in diabetic patients: role of cardiac autonomic neuropathy.
pubmed:affiliation
Cardiorespiratory Research Unit, University of Turku, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't