Linked Life Data

8884385

Source:http://linkedlifedata.com/resource/pubmed/id/8884385

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1997-1-24
pubmed:abstractText
The functional development of semicircular canals and some brainstem structures of the auditory system was followed in parallel with time in control and propylthiouracyl-induced hypothyroid pigmented rats by respective recording of postrotatory nystagmus response and auditory evoked brainstem potentials, with the aim of discovering the timing of permanent alterations of these responses in congenital hypothyroidism. A group of hypothyroid rats which under went thyroxine-replacement therapy from postnatal day 12 onward was also included in our studies to corroborate the involvement of thyroid hormones in these effects. Postrotatory nystagmus and auditory evoked responses were absent in congenital hypothyroid rats. In the thyroxine-replaced group postrotatory nystagmus values showed no differences from the control group from postnatal day 28 onward. Auditory evoked potentials in thyroxine-replaced animals could not be elicited at 30 dB, but by increasing the intensity of stimulus to 70 dB, values of latencies of the four waves composing the response were indistinguishable from controls from postnatal day 39 and thereafter. These results show that hypothyroidism affects both semicircular canal and auditory function, the latter more severely than the former, but that these effects can be prevented when thyroxine replacement treatment is started in early stages of postnatal development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0736-5748
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
515-22
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Development of vestibular and auditory function: effects of hypothyroidism and thyroxine replacement therapy on nystagmus and auditory evoked potentials in the pigmented rat.
pubmed:affiliation
Departamento de Neurociencias, UNAM, México, D.F. México.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't