Linked Life Data

8884282

Source:http://linkedlifedata.com/resource/pubmed/id/8884282

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-2-11
pubmed:abstractText
The high growth (hg) locus in mice produces a 30-50% increase in weight gain of homozygous individuals. Here we report that the microsatellite marker D10Mit69 is deleted in high growth mice. The deletion of D10Mit69 was uncovered in a screen of the high growth mouse and its progenitor strains for available markers in the hg region. We demonstrate that hg and D10Mit69 cosegregate in a cross of congenic strains C57BL/6J-hghg x C57BL/6J. These results suggest that deletion of a region around D10Mit69 is responsible for the high growth effect. Marker D10Mit69 will be utilized as an entry point to physical cloning of the hg-containing segment. A dense map of markers around hg constructed here should allow identification of markers in homologous regions in domestic animals and humans, which may be utilized to assess the role of the hg locus in these other species.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0888-7543
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
546-9
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
The high growth (hg) locus maps to a deletion in mouse chromosome 10.
pubmed:affiliation
Department of Animal Science, University of California, Davis 95616-8521, USA.
pubmed:publicationType
Journal Article