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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-1-28
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pubmed:abstractText |
A retrospective study is reported comparing the induction to delivery interval using gemeprost for termination of pregnancy, in the second trimester, in 3 groups of patients. It was observed that the mean induction to delivery interval was significantly longer in 75 pregnancies where there was a fetus with a neural tube defect and or hydrocephalus (31.7 hours) compared with 88 pregnancies with other fetal abnormalities (19.7 hours) and 84 pregnancies where there was an intrauterine death (11.3 hours). There was also an increase in the requirements for further intervention to obtain delivery in the group with a neural tube defect or hydrocephalus (n = 33) compared with where there was an intrauterine fetal death (n = 4) and other abnormality (n = 14). We believe these results should be considered when counselling patients who have requested termination of pregnancy for fetal abnormalities.
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pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/AUSTRALIA,
http://linkedlifedata.com/resource/pubmed/keyword/Abortion, Drug Induced,
http://linkedlifedata.com/resource/pubmed/keyword/Abortion, Induced,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/COUNSELING,
http://linkedlifedata.com/resource/pubmed/keyword/Clinic Activities,
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research,
http://linkedlifedata.com/resource/pubmed/keyword/Congenital Abnormalities,
http://linkedlifedata.com/resource/pubmed/keyword/Demographic Factors,
http://linkedlifedata.com/resource/pubmed/keyword/Developed Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Fertility Control, Postconception,
http://linkedlifedata.com/resource/pubmed/keyword/Fetal Death,
http://linkedlifedata.com/resource/pubmed/keyword/Genetic Counseling,
http://linkedlifedata.com/resource/pubmed/keyword/Mortality,
http://linkedlifedata.com/resource/pubmed/keyword/Neonatal Diseases And Abnormalities,
http://linkedlifedata.com/resource/pubmed/keyword/Oceania,
http://linkedlifedata.com/resource/pubmed/keyword/Organization And Administration,
http://linkedlifedata.com/resource/pubmed/keyword/PROSTAGLANDINS,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Population,
http://linkedlifedata.com/resource/pubmed/keyword/Population Dynamics,
http://linkedlifedata.com/resource/pubmed/keyword/Program Activities,
http://linkedlifedata.com/resource/pubmed/keyword/Programs,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Research Report,
http://linkedlifedata.com/resource/pubmed/keyword/Retrospective Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Time Factors
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0004-8666
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
300-3
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pubmed:dateRevised |
2009-11-11
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pubmed:otherAbstract |
PIP: Investigated, in this retrospective study, was an observation of hospital staff that use of gemeprost in mid-trimester pregnancy terminations was associated with a longer induction-delivery interval when the fetus had been diagnosed with a neural tube defect or hydrocephalus. The records of a consecutive series of 247 women admitted to Western Suburbs Hospital (Waratah, New South Wales) in the second trimester for gemeprost-induced abortion were reviewed and women were divided into three groups according to indication: Group A (n = 24)--fetal death (not from neural tube defect or hydrocephalus) diagnosed by ultrasound; Group B (n = 88)--all chromosomal and structural abnormalities other than neural tube defect and hydrocephalus; and Group C (n = 75)--neural tube defect and/or hydrocephalus diagnosed by ultrasound. The mean induction interval was 11.3 hours in Group A, 19.7 hours in Group B, and 31.7 hours in Group C. The percentages of women with an induction to delivery interval equal to or exceeding 24 hours were 4.8%, 15.9%, and 43.4%, respectively. The proportion of women requiring further surgical intervention was 4% in Group A, 14% in Group B, and 33% in Group C. These findings should be considered when counseling women who request pregnancy termination for fetal abnormalities. It was hypothesized that fetuses with a neural tube defect or hydrocephalus have a deficiency of the hypothalamic-pituitary-adrenal axis, resulting in decreased corticotrophin-releasing hormone release and difficulty initiating parturition. Use of RU-486, in addition to gemeprost or extra-amniotic prostaglandin, may be indicated in such cases.
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pubmed:meshHeading |
pubmed-meshheading:8883755-Abortifacient Agents, Nonsteroidal,
pubmed-meshheading:8883755-Abortion, Induced,
pubmed-meshheading:8883755-Adult,
pubmed-meshheading:8883755-Alprostadil,
pubmed-meshheading:8883755-Congenital Abnormalities,
pubmed-meshheading:8883755-Female,
pubmed-meshheading:8883755-Fetal Death,
pubmed-meshheading:8883755-Humans,
pubmed-meshheading:8883755-Hydrocephalus,
pubmed-meshheading:8883755-Neural Tube Defects,
pubmed-meshheading:8883755-Pregnancy,
pubmed-meshheading:8883755-Pregnancy Trimester, Second,
pubmed-meshheading:8883755-Prenatal Diagnosis,
pubmed-meshheading:8883755-Prostaglandins E, Synthetic,
pubmed-meshheading:8883755-Retrospective Studies,
pubmed-meshheading:8883755-Time Factors
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pubmed:year |
1996
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pubmed:articleTitle |
Prolonged induction to delivery time in termination of pregnancy using 16, 16-dimethyl-PGE1-methyl ester (gemeprost) for fetuses with a neural tube defect or hydrocephalus.
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pubmed:affiliation |
Division of Obstetrics and Gynaecology, John Hunter Hospital, Newcastle, New South Wales.
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pubmed:publicationType |
Journal Article
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