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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1997-1-22
|
| pubmed:abstractText |
Rats subjected to a mild to moderate fluid percussion injury exhibit memory deficits that are similar to rats that have received lesions of the septohippocampal system. Because the cholinergic system plays a major role in septohippocampal function, we studied the kinetics of the synthetic enzyme for acetylcholine, choline acetyltransferase (ChAT), at 1 h, 24 h, or 5 days after a fluid percussion injury. Decreases in ChAT activity were found in the dorsal hippocampus (25%), frontal (32%), and temporal (23%) cortices 1 h after injury. In the parietal cortex, a greater than 50% increase in ChAT activity was observed at all time intervals assessed. At 5 days after TBI, there was an 18% increase in ChAT activity in the medial septal area. These data provide evidence that a mild to moderate fluid percussion injury produces changes in the cholinergic system in brain areas related to memory.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0897-7151
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
457-63
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8880609-Analysis of Variance,
pubmed-meshheading:8880609-Animals,
pubmed-meshheading:8880609-Brain,
pubmed-meshheading:8880609-Brain Injuries,
pubmed-meshheading:8880609-Cerebellum,
pubmed-meshheading:8880609-Choline O-Acetyltransferase,
pubmed-meshheading:8880609-Entorhinal Cortex,
pubmed-meshheading:8880609-Frontal Lobe,
pubmed-meshheading:8880609-Hippocampus,
pubmed-meshheading:8880609-Kinetics,
pubmed-meshheading:8880609-Male,
pubmed-meshheading:8880609-Memory,
pubmed-meshheading:8880609-Occipital Lobe,
pubmed-meshheading:8880609-Organ Specificity,
pubmed-meshheading:8880609-Parietal Lobe,
pubmed-meshheading:8880609-Rats,
pubmed-meshheading:8880609-Rats, Sprague-Dawley,
pubmed-meshheading:8880609-Temporal Lobe,
pubmed-meshheading:8880609-Time Factors
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Effects of traumatic brain injury on the cholinergic system in the rat.
|
| pubmed:affiliation |
Department of Anesthesiology/CCM, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|