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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1997-1-23
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pubmed:abstractText |
To characterize the relaxation of pericytes induced by beta-adrenergic stimulation, changes in the contractile tone of pericytes were quantified as a change in the wrinkling of an elastic silicone surface on which they were cultured. Isoproterenol produced relaxation of pericytes in a dose-dependent manner over a range of 5 nM to 1 microM. Low concentrations of the nonselective beta-blockers propanolol and timolol blocked the relaxation produced by isoproterenol. The specific beta 2-adrenergic component of isoproterenol-induced relaxation was shown by blockage with bromoacetyl alprenolol menthane. In contrast, atenolol and betaxolol, as relatively selective beta 1-adrenergic blockers, had no effect on the isoproterenol-induced relaxation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0030-3755
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
210
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
276-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8878210-Adrenergic beta-Agonists,
pubmed-meshheading:8878210-Adrenergic beta-Antagonists,
pubmed-meshheading:8878210-Animals,
pubmed-meshheading:8878210-Blood Flow Velocity,
pubmed-meshheading:8878210-Capillaries,
pubmed-meshheading:8878210-Cattle,
pubmed-meshheading:8878210-Cells, Cultured,
pubmed-meshheading:8878210-Dose-Response Relationship, Drug,
pubmed-meshheading:8878210-Glaucoma,
pubmed-meshheading:8878210-Isoproterenol,
pubmed-meshheading:8878210-Muscle, Smooth, Vascular,
pubmed-meshheading:8878210-Muscle Contraction,
pubmed-meshheading:8878210-Optic Nerve,
pubmed-meshheading:8878210-Receptors, Adrenergic, beta,
pubmed-meshheading:8878210-Retinal Vessels
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pubmed:year |
1996
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pubmed:articleTitle |
Glaucoma, capillaries and pericytes. 4. Beta-adrenergic activation of cultured retinal pericytes.
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pubmed:affiliation |
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Fla., USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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