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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5289
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pubmed:dateCreated |
1996-12-6
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pubmed:abstractText |
Lipid A constitutes the outer monolayer of the outer membrane of Gram-negative bacteria and is essential for bacterial growth. Synthetic antibacterials were identified that inhibit the second enzyme (a unique deacetylase) of lipid A biosynthesis. The inhibitors are chiral hydroxamic acids bearing certain hydrophobic aromatic moieties. They may bind to a metal in the active site of the deacetylase. The most potent analog (with an inhibition constant of about 50 nM) displayed a minimal inhibitory concentration of about 1 microgram per milliliter against Escherichia coli, caused three logs of bacterial killing in 4 hours, and cured mice infected with a lethal intraperitoneal dose of E. coli.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0036-8075
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pubmed:author |
pubmed-author:AndersonM SMS,
pubmed-author:ChenM HMH,
pubmed-author:GallowayS MSM,
pubmed-author:GerckensL SLS,
pubmed-author:HylandS ASA,
pubmed-author:KahanF MFM,
pubmed-author:OnishiH RHR,
pubmed-author:PatchettA AAA,
pubmed-author:PelakB ABA,
pubmed-author:RaetzC RCR,
pubmed-author:SilverL LLL
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
274
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
980-2
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:8875939-Amidohydrolases,
pubmed-meshheading:8875939-Animals,
pubmed-meshheading:8875939-Anti-Bacterial Agents,
pubmed-meshheading:8875939-Binding Sites,
pubmed-meshheading:8875939-Escherichia coli,
pubmed-meshheading:8875939-Escherichia coli Infections,
pubmed-meshheading:8875939-Gram-Negative Bacteria,
pubmed-meshheading:8875939-Hydroxamic Acids,
pubmed-meshheading:8875939-Lipid A,
pubmed-meshheading:8875939-Mice,
pubmed-meshheading:8875939-Microbial Sensitivity Tests,
pubmed-meshheading:8875939-Oxazoles,
pubmed-meshheading:8875939-Pseudomonas,
pubmed-meshheading:8875939-Serratia,
pubmed-meshheading:8875939-Stereoisomerism,
pubmed-meshheading:8875939-Structure-Activity Relationship
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pubmed:year |
1996
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pubmed:articleTitle |
Antibacterial agents that inhibit lipid A biosynthesis.
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pubmed:affiliation |
Department of Microbiology, Merck Research Laboratories, Rahway, NJ 07065, USA.
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pubmed:publicationType |
Journal Article
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