Linked Life Data

8873850

Source:http://linkedlifedata.com/resource/pubmed/id/8873850

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-1-23
pubmed:abstractText
A sensitive and specific high performance liquid chromatographic method (HPLC) was developed for measuring dopamine (DA) in human plasma samples. Dihydroxybenzylamine (DHBA) was employed as an internal standard. Following solvent extraction and separation on a C18 ion-pairing reversed phase column, the drug was detected by a fluorescence detector with excitation and emission wavelengths of 233 nm and 345 nm, respectively. This method was employed to evaluate dopamine dialysability in seven haemodialysed patients under continuous infusion of a positive inotropic agent. Results showed a high dialyser extraction ratio averaging 38.3%, but a low dialysis clearance of 67 ml/min. The fraction removed by dialysis is 2.5%. We concluded that haemodialysis has little effect on dopamine blood levels, and consequently on drug pharmacokinetics, when the drug is delivered to haemodialysed patients under intravenous infusion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0269-4727
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-71
pubmed:dateRevised
2008-5-28
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Effect of dialysis on exogenous dopamine in haemodialysed critically ill patients.
pubmed:affiliation
Laboratoire de Pharmacologie, Pharmacocinétique et Pharmacie Clinique, Faculté des Sciences Pharmaceutiques et Biologiques, Lille, France.
pubmed:publicationType
Journal Article