Linked Life Data

8872868

Source:http://linkedlifedata.com/resource/pubmed/id/8872868

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1997-1-15
pubmed:abstractText
Idiopathic Parkinson's disease (PD) is a multifactorial neuro-degenerative disorder resulting from environmental factors acting on genetically susceptible individuals with normal aging. Cytochrome P450IA1 is a dioxin-inducible enzyme which is responsible for the activation of procarcinogens and environmental pollutants, such as benzo[alpha]pyrene and other aromatic hydrocarbons. The frequencies of polymorphic alleles of cytochrome P450IA1 gene (CYPIA1) were studied in 126 unrelated patients with PD in comparison with 176 healthy Japanese. The frequency of the Msp I polymorphic allele, a variant of CYPIA1 (m2), was significantly higher in patients with PD (0.444) than in controls (0.349). The risk of PD in homozygotes for m2 was 2.34-fold greater than homozygotes for the wild-type, m1. The relative risk for PD in homozygotes for CYPIA1Val was 6.54-fold higher than in homozygotes for the wild type (CYPIA1Ile)(p < 0.001). These results strongly suggest that the CYPIA1 might be one of the susceptibility genes for PD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-9564
pubmed:author
pubmed:issnType
Print
pubmed:volume
103
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
843-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Genetic association between cytochrome P450IA1 gene and susceptibility to Parkinson's disease.
pubmed:affiliation
Department of Hygiene, Ehime University School of Medicine, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't