pubmed-article:8872348 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:8872348 | lifeskim:mentions | umls-concept:C0599851 | lld:lifeskim |
pubmed-article:8872348 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
pubmed-article:8872348 | lifeskim:mentions | umls-concept:C0527250 | lld:lifeskim |
pubmed-article:8872348 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:8872348 | pubmed:dateCreated | 1997-3-25 | lld:pubmed |
pubmed-article:8872348 | pubmed:abstractText | The neural ecto-diadenosine polyphosphate hydrolase (ecto-ApnAase) from plasma membranes of Torpedo synaptic terminals is inhibited by suramin. This study was carried out by discontinuous h.p.l.c. and continuous fluorometric methods. The concentration-dependence studies showed a non-competitive mechanism for suramin in the Dixon plot, with a Ki value of 1.79 +/- 0.03 microM with respect to epsilon-(Ap3A) as the substrate and 1.69 +/- 0.05 microM and 1.86 +/- 0.06 microM for epsilon-(Ap4A) and epsilon-(Ap5A) respectively. These results indicate that suramin could be a base compound inhibiting ecto-ApnAase and providing an alternative way of studying the pharmacology of diadenosine polyphosphate receptors. | lld:pubmed |
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pubmed-article:8872348 | pubmed:language | eng | lld:pubmed |
pubmed-article:8872348 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8872348 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:8872348 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:8872348 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:8872348 | pubmed:month | Sep | lld:pubmed |
pubmed-article:8872348 | pubmed:issn | 0007-1188 | lld:pubmed |
pubmed-article:8872348 | pubmed:author | pubmed-author:Miras-Portuga... | lld:pubmed |
pubmed-article:8872348 | pubmed:author | pubmed-author:MaterMM | lld:pubmed |
pubmed-article:8872348 | pubmed:author | pubmed-author:RotllánPP | lld:pubmed |
pubmed-article:8872348 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:8872348 | pubmed:volume | 119 | lld:pubmed |
pubmed-article:8872348 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:8872348 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:8872348 | pubmed:pagination | 1-2 | lld:pubmed |
pubmed-article:8872348 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
pubmed-article:8872348 | pubmed:meshHeading | pubmed-meshheading:8872348-... | lld:pubmed |
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pubmed-article:8872348 | pubmed:meshHeading | pubmed-meshheading:8872348-... | lld:pubmed |
pubmed-article:8872348 | pubmed:year | 1996 | lld:pubmed |
pubmed-article:8872348 | pubmed:articleTitle | Suramin--a powerful inhibitor of neural ecto-diadenosine polyphosphate hydrolase. | lld:pubmed |
pubmed-article:8872348 | pubmed:affiliation | Departamento de Bioquímica, Facultad de Veterinaria, Universidad Complutense de Madrid, Spain. | lld:pubmed |
pubmed-article:8872348 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:8872348 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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