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rdf:type |
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lifeskim:mentions |
|
|
pubmed:issue |
8
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pubmed:dateCreated |
1996-12-17
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|
pubmed:abstractText |
Th2 cytokines are associated with the airway inflammation and hyperreactivity in allergic asthma and are potential targets for developing novel therapies. The efficacy of a mucosal cytokine-gene transfer approach was examined in a mouse model for allergic asthma. We showed first that mucosal IFN-gamma gene transfer results in a significant expression of IFN-gamma in the pulmonary epithelium. Significantly, this approach inhibits both Ag- and Th2-cell-induced pulmonary eosinophilia and airway hyperreactivity. These findings suggest that mucosal IFN-gamma gene transfer is effective in modulating pulmonary allergic responses and provides a basis for developing a novel therapeutic approach.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
AIM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1767
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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|
pubmed:volume |
157
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
3216-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8871613-Animals,
pubmed-meshheading:8871613-Antigens,
pubmed-meshheading:8871613-Asthma,
pubmed-meshheading:8871613-Base Sequence,
pubmed-meshheading:8871613-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:8871613-Conalbumin,
pubmed-meshheading:8871613-DNA Primers,
pubmed-meshheading:8871613-Disease Models, Animal,
pubmed-meshheading:8871613-Gene Expression,
pubmed-meshheading:8871613-Gene Transfer Techniques,
pubmed-meshheading:8871613-Genetic Vectors,
pubmed-meshheading:8871613-Hypersensitivity,
pubmed-meshheading:8871613-Interferon-gamma,
pubmed-meshheading:8871613-Lung,
pubmed-meshheading:8871613-Male,
pubmed-meshheading:8871613-Mice,
pubmed-meshheading:8871613-Mice, Inbred AKR,
pubmed-meshheading:8871613-Mucous Membrane,
pubmed-meshheading:8871613-Plasmids,
pubmed-meshheading:8871613-Th2 Cells
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|
pubmed:year |
1996
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|
pubmed:articleTitle |
Mucosal IFN-gamma gene transfer inhibits pulmonary allergic responses in mice.
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pubmed:affiliation |
Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, MD 21224, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
