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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1997-1-24
|
| pubmed:abstractText |
Mycolic acid-containing bacteria inactivate rifampicin in a variety of ways such as glucosylation, ribosylation, phosphorylation and decolorization. These inactivations were found to be a species-specific phenomena in Nocardia and related taxa. Gordona, Tsukamurella and fast-growing Mycobacterium modified rifampicin by ribosylation of the 23-OH group of the antibiotic. Such ribosylation was not observed in Rhodococcus and Corynebacterium, but phosphorylation of the 21-OH group of rifampicin was observed in one strain of Rhodococcus. Nocardia modified the antibiotic by glucosylation (23-OH group) and phosphorylation, but ribosylation was not observed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0385-5600
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1-4
|
| pubmed:dateRevised |
2002-11-1
|
| pubmed:meshHeading |
pubmed-meshheading:8871521-Actinomycetales,
pubmed-meshheading:8871521-Drug Resistance, Microbial,
pubmed-meshheading:8871521-Glycosylation,
pubmed-meshheading:8871521-Microbial Sensitivity Tests,
pubmed-meshheading:8871521-Phosphorylation,
pubmed-meshheading:8871521-Rifampin,
pubmed-meshheading:8871521-Species Specificity
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Different rifampicin inactivation mechanisms in Nocardia and related taxa.
|
| pubmed:affiliation |
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
|
| pubmed:publicationType |
Journal Article
|