Linked Life Data

8870027

Source:http://linkedlifedata.com/resource/pubmed/id/8870027

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-1-6
pubmed:abstractText
The effects of various agents that alter the intracellular Ca2+ concentration and the extracellular Ca2+ concentration on histamine-induced release of nitric oxides (NO) from porcine aortic endothelial cells were studied using NO electrodes. The NO release induced by application of histamine (200 microM) in Ca(2+)-free solution was similar to that in solution with a normal Ca2+ concentration on its first application, but reduced on its second application. NO release was also suppressed by 1,2-bis (o-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid (BAPTA), which lowers the intracellular Ca2+ concentration, and was completely inhibited by Co2+, but it was not affected by verapamil, a voltage-dependent Ca2+ channel blocker. These results suggest that Ca2+ release from intracellular stores might play an important role in NO production, that influx of extracellular Ca2+ is required to refill the stores, and that this Ca2+ influx is not through voltage-dependent Ca2+ channels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1043-6618
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
123-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Intracellular and extracellular Ca2+ regulate histamine-induced release of nitric oxide in vascular endothelial cells as shown with sensitive and selective nitric oxide electrodes.
pubmed:affiliation
Second Department of Internal Medicine, University of Tokushima, Japan.
pubmed:publicationType
Journal Article