| pubmed-article:8869663 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8869663 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8869663 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:8869663 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8869663 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:8869663 | lifeskim:mentions | umls-concept:C0071744 | lld:lifeskim |
| pubmed-article:8869663 | lifeskim:mentions | umls-concept:C1832073 | lld:lifeskim |
| pubmed-article:8869663 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8869663 | pubmed:dateCreated | 1997-2-3 | lld:pubmed |
| pubmed-article:8869663 | pubmed:abstractText | Serum cystatin C concentration correlates negatively with glomerular filtration rate as well as or better than that of serum creatinine, suggesting a constant formation, and elimination from extracellular fluid mainly by glomerular filtration. It is not known, however, how well the renal plasma clearance of this 13-kDa basic polypeptide matches the glomerular filtration rate. This was investigated in rats during control conditions and after reduced renal perfusion pressure. 125I-cystatin C and an indicator for glomerular filtration (51Cr-EDTA or 131I-aprotinin) were injected intravenously. The renal accumulation and urinary excretion of the tracers were recorded in periods of 2.5 to 20.0 min. The renal plasma clearance of 125I-cystatin C (Ccy) based on the renal content of 125I correlated well with the glomerular filtration rate (CCr-EDTA) in periods up to 6 min; i.e. Ccy = 0.94 x CCr-EDTA, r = 0.99. Less than 0.5% of the filtered amount appeared in the urine. During more prolonged periods, Ccy increasingly underestimated glomerular filtration rate, reaching about 0.4 x CCr-EDTA in a 20-min period. Free 125I relative to total plasma 125I activity increased from about 2% at 5 min to about 70% at 20 min. In nephrectomized rats, free 125I accumulated in plasma at a slower rate, accounting for about 15% of the total activity 20 min after injection of 125I-cystatin C. We conclude that cystatin C is (a) mainly removed from the extracellular fluid by the kidneys, (b) practically freely filtered in the glomeruli, and (c) completely absorbed and rapidly broken down by the proximal tubular cells. | lld:pubmed |
| pubmed-article:8869663 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8869663 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8869663 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8869663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8869663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8869663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8869663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8869663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8869663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8869663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8869663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8869663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8869663 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8869663 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8869663 | pubmed:issn | 0036-5513 | lld:pubmed |
| pubmed-article:8869663 | pubmed:author | pubmed-author:TenstadOO | lld:pubmed |
| pubmed-article:8869663 | pubmed:author | pubmed-author:GrubbAA | lld:pubmed |
| pubmed-article:8869663 | pubmed:author | pubmed-author:AuklandKK | lld:pubmed |
| pubmed-article:8869663 | pubmed:author | pubmed-author:RoaldA BAB | lld:pubmed |
| pubmed-article:8869663 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8869663 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:8869663 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8869663 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8869663 | pubmed:pagination | 409-14 | lld:pubmed |
| pubmed-article:8869663 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:8869663 | pubmed:meshHeading | pubmed-meshheading:8869663-... | lld:pubmed |
| pubmed-article:8869663 | pubmed:meshHeading | pubmed-meshheading:8869663-... | lld:pubmed |
| pubmed-article:8869663 | pubmed:meshHeading | pubmed-meshheading:8869663-... | lld:pubmed |
| pubmed-article:8869663 | pubmed:meshHeading | pubmed-meshheading:8869663-... | lld:pubmed |
| pubmed-article:8869663 | pubmed:meshHeading | pubmed-meshheading:8869663-... | lld:pubmed |
| pubmed-article:8869663 | pubmed:meshHeading | pubmed-meshheading:8869663-... | lld:pubmed |
| pubmed-article:8869663 | pubmed:meshHeading | pubmed-meshheading:8869663-... | lld:pubmed |
| pubmed-article:8869663 | pubmed:meshHeading | pubmed-meshheading:8869663-... | lld:pubmed |
| pubmed-article:8869663 | pubmed:meshHeading | pubmed-meshheading:8869663-... | lld:pubmed |
| pubmed-article:8869663 | pubmed:meshHeading | pubmed-meshheading:8869663-... | lld:pubmed |
| pubmed-article:8869663 | pubmed:meshHeading | pubmed-meshheading:8869663-... | lld:pubmed |
| pubmed-article:8869663 | pubmed:meshHeading | pubmed-meshheading:8869663-... | lld:pubmed |
| pubmed-article:8869663 | pubmed:meshHeading | pubmed-meshheading:8869663-... | lld:pubmed |
| pubmed-article:8869663 | pubmed:meshHeading | pubmed-meshheading:8869663-... | lld:pubmed |
| pubmed-article:8869663 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8869663 | pubmed:articleTitle | Renal handling of radiolabelled human cystatin C in the rat. | lld:pubmed |
| pubmed-article:8869663 | pubmed:affiliation | Department of Physiology, University of Bergen, Norway. | lld:pubmed |
| pubmed-article:8869663 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8869663 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8869663 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8869663 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8869663 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8869663 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8869663 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8869663 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8869663 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8869663 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8869663 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8869663 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8869663 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8869663 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8869663 | lld:pubmed |
