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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1996-11-27
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pubmed:abstractText |
From a murine B-cell cDNA-library we have cloned a cDNA encoding the murine B-cell specific coactivator mBob1. The protein is the murine homologue to the recently described human coactivator Bob1 (hBob1), also referred to as OBF-1 or OCA-B. We have also characterized the genomic mBob1 clone. Analysis of its intron-exon structure has allowed identification of a C-terminal splice variant. mBob1 is B-cell restricted, and is found in all B-cell lines representing different stages of B-cell differentiation. mBob1 interacts with the octamer transcription factors Oct-1 and Oct-2 and stimulates transcription mediated by these factors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HCFC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hcfc1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Host Cell Factor C1,
http://linkedlifedata.com/resource/pubmed/chemical/Octamer Transcription Factor-1,
http://linkedlifedata.com/resource/pubmed/chemical/Octamer Transcription Factor-2,
http://linkedlifedata.com/resource/pubmed/chemical/POU2AF1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/POU2F1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/POU2F2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Pou2af1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Pou2f1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Pou2f1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Pou2f2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Pou2f2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0177-3593
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
377
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
139-45
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8868069-Amino Acid Sequence,
pubmed-meshheading:8868069-Animals,
pubmed-meshheading:8868069-B-Lymphocytes,
pubmed-meshheading:8868069-Base Sequence,
pubmed-meshheading:8868069-Blotting, Northern,
pubmed-meshheading:8868069-Cell Differentiation,
pubmed-meshheading:8868069-Cell Nucleus,
pubmed-meshheading:8868069-Chromosome Mapping,
pubmed-meshheading:8868069-Cloning, Molecular,
pubmed-meshheading:8868069-DNA,
pubmed-meshheading:8868069-DNA-Binding Proteins,
pubmed-meshheading:8868069-Gene Library,
pubmed-meshheading:8868069-Host Cell Factor C1,
pubmed-meshheading:8868069-Humans,
pubmed-meshheading:8868069-Mice,
pubmed-meshheading:8868069-Mice, Inbred C57BL,
pubmed-meshheading:8868069-Molecular Sequence Data,
pubmed-meshheading:8868069-Octamer Transcription Factor-1,
pubmed-meshheading:8868069-Octamer Transcription Factor-2,
pubmed-meshheading:8868069-Rats,
pubmed-meshheading:8868069-Trans-Activators,
pubmed-meshheading:8868069-Transcription Factors,
pubmed-meshheading:8868069-Tumor Cells, Cultured
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pubmed:year |
1996
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pubmed:articleTitle |
Cloning and characterization of the murine B-cell specific transcriptional coactivator Bob1.
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pubmed:affiliation |
Institut für Molekularbiologie II der Universität Zürich, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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