Linked Life Data

8867101

Source:http://linkedlifedata.com/resource/pubmed/id/8867101

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-12-3
pubmed:abstractText
The effects of endothelin-1 and endothelin-3 were investigated on carbachol-contracted guinea-pig isolated trachea. Endothelin-1 and endothelin-3 (0.1-100 nM) induced partial dose-dependent relaxation of the precontracted preparations. The endothelin-1-induced relaxation was markedly attenuated by haemoglobin (10 microM) and methylene blue (10 microM) and by epithelium removal. In contrast, endothelin-3-induced relaxation was not affected by haemoglobin, methylene blue or epithelium removal. The large conductance Ca(2+)-activated K(+)-channel blocker, charybdotoxin, antagonized the endothelin-1- and the endothelin-3-induced relaxation to the same extent. These results show that both endothelin-1 and endothelin-3 relaxant activities are modulated by charybdotoxin-sensitive K(+)-channels, while the nitric oxide pathway is only involved in endothelin-1 relaxant effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
298
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Different mechanisms involved in relaxation of guinea-pig trachea by endothelin-1 and -3.
pubmed:affiliation
Laboratoire de Pharmacodynamie, Faculté de Pharmacie, Montpellier, France.
pubmed:publicationType
Journal Article