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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1996-11-29
|
| pubmed:abstractText |
We investigated the response of leptin to short-term fasting and refeeding in humans. A mild decline in subcutaneous adipocyte ob gene mRNA and a marked fall in serum leptin were observed after 36 and 60 h of fasting. The dynamics of the leptin decline and rise were further substantiated in a 6-day study consisting of a 36-h baseline period, followed by 36-h fast, and a subsequent refeeding with normal diet. Leptin began a steady decline from the baseline values after 12 h of fasting, reaching a nadir at 36 h. The subsequent restoration of normal food intake was associated with a prompt leptin rise and a return to baseline values 24 h later. When responses of leptin to fasting and refeeding were compared with that of glucose, insulin, fatty acids, and ketones, a reverse relationship between leptin and beta-OH-butyrate was found. Consequently, we tested whether the reciprocal responses represented a causal relationship between leptin and beta-OH-butyrate. Small amounts of infused glucose equal to the estimated contribution of gluconeogenesis, which was sufficient to prevent rise in ketogenesis, also prevented a fall in leptin. The infusion of beta-OH-butyrate to produce hyperketonemia of the same magnitude as after a 36-h fast had no effect on leptin. The study indicates that one of the adaptive physiological responses to fasting is a fall in serum leptin. Although the mediator that brings about this effect remains unknown, it appears to be neither insulin nor ketones.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-Hydroxybutyric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Nonesterified,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxybutyrates,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Ketone Bodies,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0012-1797
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
45
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1511-5
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8866554-3-Hydroxybutyric Acid,
pubmed-meshheading:8866554-Adipose Tissue,
pubmed-meshheading:8866554-Adult,
pubmed-meshheading:8866554-Analysis of Variance,
pubmed-meshheading:8866554-Blood Glucose,
pubmed-meshheading:8866554-Eating,
pubmed-meshheading:8866554-Fasting,
pubmed-meshheading:8866554-Fatty Acids, Nonesterified,
pubmed-meshheading:8866554-Female,
pubmed-meshheading:8866554-Humans,
pubmed-meshheading:8866554-Hydroxybutyrates,
pubmed-meshheading:8866554-Insulin,
pubmed-meshheading:8866554-Ketone Bodies,
pubmed-meshheading:8866554-Leptin,
pubmed-meshheading:8866554-Male,
pubmed-meshheading:8866554-Obesity,
pubmed-meshheading:8866554-Pilot Projects,
pubmed-meshheading:8866554-Polymerase Chain Reaction,
pubmed-meshheading:8866554-Protein Biosynthesis,
pubmed-meshheading:8866554-Proteins,
pubmed-meshheading:8866554-RNA, Messenger,
pubmed-meshheading:8866554-Time Factors,
pubmed-meshheading:8866554-Transcription, Genetic
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Responses of leptin to short-term fasting and refeeding in humans: a link with ketogenesis but not ketones themselves.
|
| pubmed:affiliation |
Division of Endocrinology and Metabolic Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|