Linked Life Data

8865370

Source:http://linkedlifedata.com/resource/pubmed/id/8865370

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-1-2
pubmed:abstractText
We investigated the inhibition of lipid peroxidation by monoamines. We found that monoamines, including dopa, dopamine, adrenaline and serotonin, strongly inhibited lipid peroxidation induced by 2,2'-azobis-(2-amidinopropane)-dihydrochroride (AAPH). In contrast, lipid peroxidation induced by 2,2'-azobis-(2,4-dimethylvaleronitrile) was not effectively inhibited by the monoamines. Degradation of R-phycoerythrin induced by AAPH was strongly prevented by these monoamines, suggesting that monoamines scavenge peroxyl radicals in the buffer and on the surface of membrane lipid layers. Methoxy derivatives of dihydroxyphenylacetic acid and 5-methoxytryptophan produced little inhibition of lipid peroxidation induced by AAPH, suggesting that hydroxy groups of monoamines donate protons to peroxyl radicals to prevent lipid peroxidation. However, the monoamines did not sharply inhibit lipid peroxidation induced by ascorbate-ADP-Fe3+ and t-butylhydroperoxide-Fe2+. Lipid peroxidation predominantly proceeding by peroxyl radicals in these reaction systems seems unlikely.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1078-0297
pubmed:author
pubmed:issnType
Print
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
57-67
pubmed:dateRevised
2000-12-18
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Lipid peroxidation inhibited by monoamines.
pubmed:affiliation
Department of Biochemistry, Hokkaido College of Pharmacy, Otaru, Japan.
pubmed:publicationType
Journal Article