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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0086123,
umls-concept:C0087140,
umls-concept:C0162508,
umls-concept:C0185117,
umls-concept:C0205148,
umls-concept:C0205216,
umls-concept:C0205217,
umls-concept:C0205307,
umls-concept:C0220802,
umls-concept:C0332281,
umls-concept:C1280500,
umls-concept:C1515655,
umls-concept:C1880192,
umls-concept:C1882628,
umls-concept:C2911684
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pubmed:issue |
4
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pubmed:dateCreated |
1997-1-8
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pubmed:abstractText |
Studies on colon carcinogenesis suggest that the short-chain fatty acid butyrate may be protective, whereas the secondary bile acid deoxycholate may promote tumor development. Crypt surface hyperproliferation is regarded as a biomarker of colon cancer risk and can be modulated in vitro by the differentiation inducer butyrate and the tumor promoter deoxycholate. We hypothesized that butyrate decreases and deoxycholate increases crypt surface proliferation in vivo and that these effects are mediated by changes in the expression of the protooncogenes c-Fos and c-Jun, which are known to regulate proliferation and differentiation.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0148-6071
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
243-50
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pubmed:dateRevised |
2007-2-21
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pubmed:meshHeading |
pubmed-meshheading:8865104-Animals,
pubmed-meshheading:8865104-Blotting, Western,
pubmed-meshheading:8865104-Butyric Acid,
pubmed-meshheading:8865104-Butyric Acids,
pubmed-meshheading:8865104-Cell Division,
pubmed-meshheading:8865104-Cholagogues and Choleretics,
pubmed-meshheading:8865104-Colon,
pubmed-meshheading:8865104-Deoxycholic Acid,
pubmed-meshheading:8865104-Male,
pubmed-meshheading:8865104-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:8865104-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:8865104-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:8865104-Rats,
pubmed-meshheading:8865104-Rats, Sprague-Dawley
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pubmed:articleTitle |
In vivo crypt surface hyperproliferation is decreased by butyrate and increased by deoxycholate in normal rat colon: associated in vivo effects on c-Fos and c-Jun expression.
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pubmed:affiliation |
Harrison Department of Surgical Research, University of Pennsylvania Medical Center, Philadelphia, USA.
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pubmed:publicationType |
Journal Article
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