Linked Life Data

8864484

Source:http://linkedlifedata.com/resource/pubmed/id/8864484

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-1-15
pubmed:abstractText
DNQX, an antagonist of AMPA/kainate receptors, was injected into the ventral tegmental area (VTA) to test the hypothesis that AMPA/kainate receptors in this brain region might be involved in regulation of locomotor activity. Bilateral injection of 1 microgram DNQX into the VTA increased locomotor activity. In addition, unilateral injection of DNQX into this site produced contraversive turning, which was potentiated by coadministration of amphetamine (1 mg/kg, i.p.). These results suggest that a glutamatergic afferent to the VTA is tonically active in inhibiting locomotor activity. The locomotor stimulation produced by DNQX was not associated with a change in DOPAC/DA level in the nucleus accumbens or the striatum. However, the locomotor stimulation produced by DNQX was markedly attenuated following blockade of dopaminergic receptors by haloperidol (0.5 mg/kg, s.c.) or following dopamine depletion induced by reserpine plus alpha-methyl-para-tyrosine pretreatment. These results suggest that a basal activation of dopaminergic receptors is required for expression of the locomotor activity elicited by DNQX.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
728
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
209-14
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Induction of locomotor activity by the glutamate antagonist DNQX injected into the ventral tegmental area.
pubmed:affiliation
Division of Pharmacology, College of Pharmacy, Ohio State University, Columbus 43210-1291, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.