rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
4
|
pubmed:dateCreated |
1996-11-20
|
pubmed:abstractText |
Acute kidney failure in surgical patients is often related to severe infection. Renal vasoconstriction is a major factor in the genesis of kidney failure. Reactive oxygen species (ROS) are known to mediate kidney injury after ischemia-reperfusion and are increased during sepsis. The role of ROS as mediators of intrarenal vasoconstriction and renal dysfunction during sepsis is unclear. Lazaroids such as U74389G are radical quenching antioxidants that inhibit ROS-induced lipid peroxidation. We sought to determine whether radical scavenging affected the renal microvascular response to a septic challenge.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0039-6060
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
120
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
657-62
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8862374-Animals,
pubmed-meshheading:8862374-Antioxidants,
pubmed-meshheading:8862374-Bacteremia,
pubmed-meshheading:8862374-Free Radical Scavengers,
pubmed-meshheading:8862374-Hemodynamics,
pubmed-meshheading:8862374-Lipid Peroxidation,
pubmed-meshheading:8862374-Male,
pubmed-meshheading:8862374-Microcirculation,
pubmed-meshheading:8862374-Pregnatrienes,
pubmed-meshheading:8862374-Rats,
pubmed-meshheading:8862374-Rats, Wistar,
pubmed-meshheading:8862374-Reactive Oxygen Species,
pubmed-meshheading:8862374-Renal Circulation,
pubmed-meshheading:8862374-Sepsis,
pubmed-meshheading:8862374-Vasoconstriction
|
pubmed:year |
1996
|
pubmed:articleTitle |
Free radical scavenging by lazaroids improves renal blood flow during sepsis.
|
pubmed:affiliation |
Department of Surgery, University of Louisville, Ky. 40292, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|