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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1996-11-19
|
| pubmed:abstractText |
In this study we used nonradioactive in situ hybridization for the cellular localization of vascular cell adhesion molecule-1 (VCAM-1) mRNA in immune-mediated, ischemic and degenerative diseases of the rat nervous system. In the acute phase of experimental autoimmune encephalomyelitis and neuritis VCAM-1 mRNA was expressed not only on the luminal surface of inflamed vessels but also in perivascular cells suggesting a functional role of VCAM-1 in both endothelial adhesion and local restimulation of autoantigen-specific T cells. Accordingly, perivascular T cell accumulation was most pronounced at sites of local VCAM-1 mRNA expression. In addition, VCAM-1 mRNA was detected in the border zone around photochemically induced cerebral infarcts which is the predeliction site of T cell infiltration and expression of immune activation markers during the first week after ischemia. VCAM-1 mRNA was absent from the center of the infarcts as well as axotomized central and peripheral nerves undergoing Wallerian degeneration. These data indicate that VCAM-1-mediated adhesion processes are involved in immune-mediated and ischemic diseases of the nervous system but not in T cell-independent macrophage recruitment during Wallerian degeneration.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0165-5728
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
70
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
75-80
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8862137-Acute Disease,
pubmed-meshheading:8862137-Animals,
pubmed-meshheading:8862137-Autoimmune Diseases,
pubmed-meshheading:8862137-Cattle,
pubmed-meshheading:8862137-Cerebral Arteries,
pubmed-meshheading:8862137-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:8862137-Female,
pubmed-meshheading:8862137-Immunization,
pubmed-meshheading:8862137-In Situ Hybridization,
pubmed-meshheading:8862137-Intracranial Embolism and Thrombosis,
pubmed-meshheading:8862137-Macrophage Activation,
pubmed-meshheading:8862137-Nerve Crush,
pubmed-meshheading:8862137-Neuritis, Autoimmune, Experimental,
pubmed-meshheading:8862137-Optic Nerve,
pubmed-meshheading:8862137-Optic Nerve Injuries,
pubmed-meshheading:8862137-RNA, Messenger,
pubmed-meshheading:8862137-Rats,
pubmed-meshheading:8862137-Rats, Inbred Lew,
pubmed-meshheading:8862137-Rats, Wistar,
pubmed-meshheading:8862137-Sciatic Nerve,
pubmed-meshheading:8862137-Vascular Cell Adhesion Molecule-1,
pubmed-meshheading:8862137-Wallerian Degeneration
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Vascular cell adhesion molecule-1 mRNA is expressed in immune-mediated and ischemic injury of the rat nervous system.
|
| pubmed:affiliation |
Department of Neurology, Heinrich-Heine-University, Düsseldorf, Germany.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|