Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1997-5-13
|
pubmed:abstractText |
Patients with metastatic renal cell cancer and metastatic melanoma treated with high-dose interleukin-2-based immunotherapy were prospectively evaluated for the development of vitiligo. All patients seen in the Surgery Branch, NCI Immunotherapy Clinic, who had been followed for at least 1 year were evaluated. Of 104 patients with metastatic renal cancer none developed vitiligo, though vitiligo was seen in 11 of 74 (15%) patients with metastatic melanoma (p2 = 0.0001). No vitiligo was seen in 27 patients who did not respond to immunotherapy, although vitiligo was seen in 11 of 43 (26%) melanoma patients who had an objective response to IL-2-based immunotherapy (p2 = 0.0002). These findings provide further evidence that the presence of a growing melanoma can sensitize patients to melanocyte-differentiation antigens and that the immune response against these antigens is associated with cancer regression in patients undergoing immunotherapy.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
1067-5582
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
19
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
81-4
|
pubmed:dateRevised |
2004-11-17
|
pubmed:meshHeading |
pubmed-meshheading:8859727-Antigens, Neoplasm,
pubmed-meshheading:8859727-Carcinoma, Renal Cell,
pubmed-meshheading:8859727-Humans,
pubmed-meshheading:8859727-Immunotherapy, Active,
pubmed-meshheading:8859727-Interleukin-2,
pubmed-meshheading:8859727-Kidney Neoplasms,
pubmed-meshheading:8859727-Male,
pubmed-meshheading:8859727-Melanoma,
pubmed-meshheading:8859727-Middle Aged,
pubmed-meshheading:8859727-Skin Neoplasms,
pubmed-meshheading:8859727-Vitiligo
|
pubmed:year |
1996
|
pubmed:articleTitle |
Vitiligo in patients with melanoma: normal tissue antigens can be targets for cancer immunotherapy.
|
pubmed:affiliation |
Surgery Branch, Clinical Oncology Program, National Cancer Institute, Bethesda, Maryland, USA.
|
pubmed:publicationType |
Journal Article
|