| pubmed-article:8857935 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8857935 | lifeskim:mentions | umls-concept:C0003232 | lld:lifeskim |
| pubmed-article:8857935 | lifeskim:mentions | umls-concept:C2359945 | lld:lifeskim |
| pubmed-article:8857935 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:8857935 | lifeskim:mentions | umls-concept:C0079459 | lld:lifeskim |
| pubmed-article:8857935 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:8857935 | lifeskim:mentions | umls-concept:C0079460 | lld:lifeskim |
| pubmed-article:8857935 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:8857935 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8857935 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:8857935 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8857935 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:8857935 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8857935 | pubmed:dateCreated | 1996-12-12 | lld:pubmed |
| pubmed-article:8857935 | pubmed:abstractText | We studied the effects of eight antibiotics, cyclosporin and corticosteroids on the in vitro secretion of GM-CSF and G-CSF by monocytes. T lymphocytes and endothelial cells. The aim was to evaluate a possible mechanism for these drugs in the delay of haemopoietic recovery after high-dose chemotherapy or bone marrow transplantation. Corticosteroids were prominent inhibitors of GM-CSF secretion by monocytes and T lymphocytes, but not by endothelial cells. In contrast, G-CSF secretion by monocytes was unchanged whereas that of endothelial cells was enhanced in the presence of corticosteroids. Cyclosporin efficiently down-regulated GM-CSF secretion by T lymphocytes and had also a minor effect on CSF secretion by endothelial cells, whereas monocyte secretion was unaffected. Stimulated T lymphocytes derived from patients under treatment with cyclosporin had impaired capacity to secrete GM-CSF compared to controls. Among the antibiotics, cephalosporins inhibited GM-CSF secretion by T lymphocytes, and GM- and G-CSF secretion by endothelial cells. Ciprofloxacin and sulphmethoxazole had minor effects on GM-CSF secretion by T lymphocytes and endothelial cells. No antibiotic significantly influenced GM-CSF secretion by monocytes. | lld:pubmed |
| pubmed-article:8857935 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8857935 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8857935 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8857935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8857935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8857935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8857935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8857935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8857935 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8857935 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8857935 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8857935 | pubmed:issn | 0007-1048 | lld:pubmed |
| pubmed-article:8857935 | pubmed:author | pubmed-author:OlofssonTT | lld:pubmed |
| pubmed-article:8857935 | pubmed:author | pubmed-author:LenhoffSS | lld:pubmed |
| pubmed-article:8857935 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8857935 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:8857935 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8857935 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8857935 | pubmed:pagination | 33-8 | lld:pubmed |
| pubmed-article:8857935 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8857935 | pubmed:meshHeading | pubmed-meshheading:8857935-... | lld:pubmed |
| pubmed-article:8857935 | pubmed:meshHeading | pubmed-meshheading:8857935-... | lld:pubmed |
| pubmed-article:8857935 | pubmed:meshHeading | pubmed-meshheading:8857935-... | lld:pubmed |
| pubmed-article:8857935 | pubmed:meshHeading | pubmed-meshheading:8857935-... | lld:pubmed |
| pubmed-article:8857935 | pubmed:meshHeading | pubmed-meshheading:8857935-... | lld:pubmed |
| pubmed-article:8857935 | pubmed:meshHeading | pubmed-meshheading:8857935-... | lld:pubmed |
| pubmed-article:8857935 | pubmed:meshHeading | pubmed-meshheading:8857935-... | lld:pubmed |
| pubmed-article:8857935 | pubmed:meshHeading | pubmed-meshheading:8857935-... | lld:pubmed |
| pubmed-article:8857935 | pubmed:meshHeading | pubmed-meshheading:8857935-... | lld:pubmed |
| pubmed-article:8857935 | pubmed:meshHeading | pubmed-meshheading:8857935-... | lld:pubmed |
| pubmed-article:8857935 | pubmed:meshHeading | pubmed-meshheading:8857935-... | lld:pubmed |
| pubmed-article:8857935 | pubmed:meshHeading | pubmed-meshheading:8857935-... | lld:pubmed |
| pubmed-article:8857935 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8857935 | pubmed:articleTitle | Effects of immunosuppressive drugs and antibiotics on GM-CSF and G-CSF secretion in vitro by monocytes, T lymphocytes and endothelial cells. | lld:pubmed |
| pubmed-article:8857935 | pubmed:affiliation | Department of Medicine, University Hospital, Lund, Sweden. | lld:pubmed |
| pubmed-article:8857935 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8857935 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
