Linked Life Data

8856160

Source:http://linkedlifedata.com/resource/pubmed/id/8856160

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
1997-2-10
pubmed:abstractText
The present study investigated the development of hyperthermia and thermal and mechanical hyperalgesia following i.c.v. injections of E. coli lipopolysaccharide (LPS) in rats. LPS increased core temperature and this was prevented by i.c.v. administration of HOE 140, a kinin B2 receptor antagonist or by indomethacin i.c.v. or i.v. B1 receptor antagonists had no effect. LPS induced thermal and mechanical hyperalgesia which was reversed by i.c.v. HOE 140 and indomethacin i.c.v. and i.v., but not by B1 receptor antagonists. These results indicate that injections of endotoxin to the CNS induces hyperthermia and hyperalgesia and that kinins, acting on centrally located B2 receptors, and prostanoids are involved.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0162-3109
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
264-9
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Development of hyperthermia and hyperalgesia following intracerebroventricular administration of endotoxin in the rat: effect of kinin B1 and B2 receptor antagonists.
pubmed:affiliation
Sandoz Institute for Medical Research, London, UK.
pubmed:publicationType
Journal Article