| pubmed-article:8855288 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8855288 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:8855288 | lifeskim:mentions | umls-concept:C0003765 | lld:lifeskim |
| pubmed-article:8855288 | lifeskim:mentions | umls-concept:C0019740 | lld:lifeskim |
| pubmed-article:8855288 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:8855288 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:8855288 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:8855288 | lifeskim:mentions | umls-concept:C0052794 | lld:lifeskim |
| pubmed-article:8855288 | lifeskim:mentions | umls-concept:C1511539 | lld:lifeskim |
| pubmed-article:8855288 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8855288 | lifeskim:mentions | umls-concept:C1176299 | lld:lifeskim |
| pubmed-article:8855288 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:8855288 | pubmed:dateCreated | 1996-11-25 | lld:pubmed |
| pubmed-article:8855288 | pubmed:abstractText | The class I major histocompatibility complex (MHC) glycoprotein HLA-B27 binds short peptides containing arginine at peptide position 2 (P2). The HLA-B27/peptide complex is recognized by T cells both as part of the development of the repertoire of T cells in the cellular immune system and during activation of cytotoxic T cells. Based on the three-dimensional structure of HLA-B27, we have synthesized a ligand with an aziridine-containing side chain designed to mimic arginine and to bind covalently in the arginine-specific P2 pocket of HLA-B27. Using tryptic digestion followed by mass spectrometry and amino acid sequencing, the aziridine-containing ligand is shown to alkylate specifically cysteine 67 of HLA-B27. Neither free cysteine in solution nor an exposed cysteine on a class II MHC molecule can be alkylated, showing that specific recognition between the anchor side-chain pocket of an MHC class I protein and the designed ligand (propinquity) is necessary to induce the selective covalent reaction with the MHC class I molecule. | lld:pubmed |
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| pubmed-article:8855288 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8855288 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8855288 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8855288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8855288 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8855288 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8855288 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8855288 | pubmed:author | pubmed-author:CollinsE JEJ | lld:pubmed |
| pubmed-article:8855288 | pubmed:author | pubmed-author:MatzR JRJ | lld:pubmed |
| pubmed-article:8855288 | pubmed:author | pubmed-author:WileyD CDC | lld:pubmed |
| pubmed-article:8855288 | pubmed:author | pubmed-author:SchreiberS... | lld:pubmed |
| pubmed-article:8855288 | pubmed:author | pubmed-author:GarbocziD NDN | lld:pubmed |
| pubmed-article:8855288 | pubmed:author | pubmed-author:WeissG AGA | lld:pubmed |
| pubmed-article:8855288 | pubmed:author | pubmed-author:Valentekovich... | lld:pubmed |
| pubmed-article:8855288 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8855288 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8855288 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:8855288 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8855288 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8855288 | pubmed:pagination | 10945-8 | lld:pubmed |
| pubmed-article:8855288 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8855288 | pubmed:meshHeading | pubmed-meshheading:8855288-... | lld:pubmed |
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| pubmed-article:8855288 | pubmed:meshHeading | pubmed-meshheading:8855288-... | lld:pubmed |
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| pubmed-article:8855288 | pubmed:meshHeading | pubmed-meshheading:8855288-... | lld:pubmed |
| pubmed-article:8855288 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8855288 | pubmed:articleTitle | Covalent HLA-B27/peptide complex induced by specific recognition of an aziridine mimic of arginine. | lld:pubmed |
| pubmed-article:8855288 | pubmed:affiliation | Department of Chemistry, Harvard University, Cambridge, MA 02138, USA. | lld:pubmed |
| pubmed-article:8855288 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8855288 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8855288 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8855288 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8855288 | lld:pubmed |
