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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
1996-11-25
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pubmed:abstractText |
The junction-associated protein zonula occludens-1 (ZO-1) is a member of a family of membrane-associated guanylate kinase homologues thought to be important in signal transduction at sites of cell-cell contact. We present evidence that under certain conditions of cell growth, ZO-1 can be detected in the nucleus. Two different antibodies against distinct portions of the ZO-1 polypeptide reveal nuclear staining in subconfluent, but not confluent, cell cultures. An exogenously expressed, epitope-tagged ZO-1 can also be detected in the nuclei of transfected cells. Nuclear accumulation can be stimulated at sites of wounding in cultured epithelial cells, and immunoperoxidase detection of ZO-1 in tissue sections of intestinal epithelial cells reveals nuclear labeling only along the outer tip of the villus. These results suggest that the nuclear localization of ZO-1 is inversely related to the extent and/or maturity of cell contact. Since cell-cell contacts are specialized sites for signaling pathways implicated in growth and differentiation, we suggest that the nuclear accumulation of ZO-1 may be relevant for its suggested role in membrane-associated guanylate kinase homologue signal transduction.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-1282353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-1419001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-1539634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-1590354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-1651169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-1713685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-1860878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-1920385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-2166816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-2380981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-3049625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-3058722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-3203379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-3315650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-3528172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-388439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-6814762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-7477295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-7569905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-7593185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-7680343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-7682777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-7716513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-7806577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-7876319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-7880525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-7937897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-7954790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-8080429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-8132716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-8240820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-8245116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-8343960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-8395056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-8406001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-8413612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-8486731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-8573338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-8590799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-8636221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8855257-8700833
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10779-84
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8855257-Animals,
pubmed-meshheading:8855257-Cell Adhesion,
pubmed-meshheading:8855257-Cell Compartmentation,
pubmed-meshheading:8855257-Cell Line,
pubmed-meshheading:8855257-Cell Nucleus,
pubmed-meshheading:8855257-Cercopithecus aethiops,
pubmed-meshheading:8855257-Dogs,
pubmed-meshheading:8855257-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:8855257-Guanylate Kinase,
pubmed-meshheading:8855257-Immunoenzyme Techniques,
pubmed-meshheading:8855257-Membrane Proteins,
pubmed-meshheading:8855257-Nucleoside-Phosphate Kinase,
pubmed-meshheading:8855257-Phosphoproteins,
pubmed-meshheading:8855257-Signal Transduction,
pubmed-meshheading:8855257-Tight Junctions
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pubmed:year |
1996
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pubmed:articleTitle |
The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts.
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pubmed:affiliation |
Laboratory of Cell Signaling and Morphogenesis, UMR 144 Centre National de la Recherche Scientifique, Institut Curie, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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