Linked Life Data

8854024

Source:http://linkedlifedata.com/resource/pubmed/id/8854024

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1997-2-10
pubmed:abstractText
Wildlife vaccination depends on vaccines which can be orally administered by a baiting system. Therefore only two possibilities exist: either the use of attenuated strains of viruses, or recombinant vector viruses. As far as rabies is concerned, the choice of the recombinant vaccinia-rabies virus was made because it was safer and more stable. An in vitro stability study of the recombinant product compared to wild rabies virus at different temperatures (4 degrees C, 20 degrees C, 37 degrees C, 45 degrees C) showed that the recombinant virus was more stable. The stability of the recombinant virus was also tested under field conditions; besides natural freezing and thawing cycles, the virus titre remained unchanged in the bait for a month. Taking into account the fact that all baits are eaten by wild animals within this period, one can assume that the vaccine is efficacious for all baiting animals in field conditions. The stability of the recombinant vaccinia-rabies vaccine is of considerable interest in such uncontrolled conditions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-5149
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
245-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Stability of recombinant vaccinia-rabies vaccine in veterinary use.
pubmed:affiliation
Department of Immunology-Vaccinology, Faculty of Veterinary Medicine, University of Liège, Belgium.
pubmed:publicationType
Journal Article