| pubmed-article:8853383 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8853383 | lifeskim:mentions | umls-concept:C0026549 | lld:lifeskim |
| pubmed-article:8853383 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:8853383 | lifeskim:mentions | umls-concept:C0597295 | lld:lifeskim |
| pubmed-article:8853383 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8853383 | lifeskim:mentions | umls-concept:C0066816 | lld:lifeskim |
| pubmed-article:8853383 | lifeskim:mentions | umls-concept:C0205099 | lld:lifeskim |
| pubmed-article:8853383 | pubmed:issue | 3 Pt 2 | lld:pubmed |
| pubmed-article:8853383 | pubmed:dateCreated | 1996-12-5 | lld:pubmed |
| pubmed-article:8853383 | pubmed:abstractText | The central and peripheral effects of morphine sulfate (Mor) and morphine-6-glucuronide (M6G) on the fractional rates of tissue protein synthesis (kappa s) were determined. We determined ks in conscious rats 2 h after intracerebroventricular injection of Mor (80 micrograms/rat), M6G (1 microgram/rat), or H2O (5 microliters). Intracerebroventricular Mor and M6G administration decreased ks in the liver by 19 and 18% spleen by 19 and 17%, and gastrocnemius by 18 and 17%, respectively. Intravenous injection of Mor (8 mg/kg) or M6G (0.4 mg/kg) did not affect ks in any of the tissues studied. Intracerebroventricular Mor and M6G resulted in an equivalent 10- to 15-fold increase in plasma epinephrine, 2- to 3-fold increase in norepinephrine, and 80-90% increase in corticosterone, with no change in insulin levels. Intracerebroventricular Mor produced a significant 30% decrease in arterial partial O2 pressure (PaO2) and no significant changes in arterial pH and arterial partial CO2 pressure (PacO2). Intracerebroventricular M6G decreased PaO2 (40%) and pH (from 7.44 +/- 0.01 to 7.34 +/- 0.02) and increased Paco2 (36%). The potential contribution of hypoxia to the opiate-induced decrease in ks was assessed in an additional set of rats exposed to 5% O2-95% N2. One or 2 h of hypoxia decreased protein synthesis in the brain by 47 and 56%, liver by 69 and 69%, and skeletal muscle by 51 and 52%, respectively. Our results indicate that Mor and M6G suppress tissue protein synthesis through central mechanisms, most likely mediated by opiate-induced respiratory depression in association with neural and hormonal alterations. | lld:pubmed |
| pubmed-article:8853383 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8853383 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8853383 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8853383 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8853383 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8853383 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8853383 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8853383 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8853383 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8853383 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8853383 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8853383 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8853383 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8853383 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:8853383 | pubmed:author | pubmed-author:SugdenP HPH | lld:pubmed |
| pubmed-article:8853383 | pubmed:author | pubmed-author:GarlickP JPJ | lld:pubmed |
| pubmed-article:8853383 | pubmed:author | pubmed-author:McNurlanM AMA | lld:pubmed |
| pubmed-article:8853383 | pubmed:author | pubmed-author:HashiguchiYY | lld:pubmed |
| pubmed-article:8853383 | pubmed:author | pubmed-author:PreedyV RVR | lld:pubmed |
| pubmed-article:8853383 | pubmed:author | pubmed-author:AbumradN NNN | lld:pubmed |
| pubmed-article:8853383 | pubmed:author | pubmed-author:MolinaP EPE | lld:pubmed |
| pubmed-article:8853383 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8853383 | pubmed:volume | 271 | lld:pubmed |
| pubmed-article:8853383 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8853383 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8853383 | pubmed:pagination | R619-25 | lld:pubmed |
| pubmed-article:8853383 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8853383 | pubmed:meshHeading | pubmed-meshheading:8853383-... | lld:pubmed |
| pubmed-article:8853383 | pubmed:meshHeading | pubmed-meshheading:8853383-... | lld:pubmed |
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| pubmed-article:8853383 | pubmed:meshHeading | pubmed-meshheading:8853383-... | lld:pubmed |
| pubmed-article:8853383 | pubmed:meshHeading | pubmed-meshheading:8853383-... | lld:pubmed |
| pubmed-article:8853383 | pubmed:meshHeading | pubmed-meshheading:8853383-... | lld:pubmed |
| pubmed-article:8853383 | pubmed:meshHeading | pubmed-meshheading:8853383-... | lld:pubmed |
| pubmed-article:8853383 | pubmed:meshHeading | pubmed-meshheading:8853383-... | lld:pubmed |
| pubmed-article:8853383 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8853383 | pubmed:articleTitle | Central effects of morphine and morphine-6-glucuronide on tissue protein synthesis. | lld:pubmed |
| pubmed-article:8853383 | pubmed:affiliation | Department of Surgery, State University of New York at Stony Brook 11794-8194, USA. | lld:pubmed |
| pubmed-article:8853383 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8853383 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
