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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1996-12-16
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pubmed:abstractText |
The turning behavior induced by the intrastriatal injection of the D1 agonist (+)SKF 38393 was blocked by the two selective nonpeptide tachykinin NK1 (SR 140333) (ID50 = 0.09 mg/kg ip) and NK2 (SR 48968) (ID50 = 1.4 mg/kg ip) receptor antagonists and by atropine (ID50 = 2.6 mg/kg ip). In addition, the turning induced by the intrastriatal injection of NK1 (septide) and NK2 ([Nle10]NKA(4-10)) receptor agonists were antagonized by atropine (ID50s = 1.1 mg/kg ip and 0.78 mg/kg ip, respectively). This behavioral study shows that tachykinin receptor activation is an essential component of DA-D1/Ach interaction in the mouse striatum and confirms the previously suggested functional importance of NK2 receptors in the central nervous system.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,3,4,5-Tetrahydro-7,8-dihydroxy-1-p...,
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Benzamides,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Quinuclidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D1,
http://linkedlifedata.com/resource/pubmed/chemical/SR 140333,
http://linkedlifedata.com/resource/pubmed/chemical/SR 48968,
http://linkedlifedata.com/resource/pubmed/chemical/Tachykinins
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
205
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
185-8
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:8852589-2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine,
pubmed-meshheading:8852589-Acetylcholine,
pubmed-meshheading:8852589-Animals,
pubmed-meshheading:8852589-Behavior, Animal,
pubmed-meshheading:8852589-Benzamides,
pubmed-meshheading:8852589-Cholinergic Fibers,
pubmed-meshheading:8852589-Dopamine Agonists,
pubmed-meshheading:8852589-Dose-Response Relationship, Drug,
pubmed-meshheading:8852589-Female,
pubmed-meshheading:8852589-Mice,
pubmed-meshheading:8852589-Mice, Inbred Strains,
pubmed-meshheading:8852589-Neostriatum,
pubmed-meshheading:8852589-Piperidines,
pubmed-meshheading:8852589-Quinuclidines,
pubmed-meshheading:8852589-Receptors, Dopamine D1,
pubmed-meshheading:8852589-Rotation,
pubmed-meshheading:8852589-Stereoisomerism,
pubmed-meshheading:8852589-Tachykinins
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pubmed:year |
1996
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pubmed:articleTitle |
Evidence for a tachykinin/cholinergic mediation of D1 agonist-induced turning in mice.
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pubmed:affiliation |
Sanofi Recherche, Montpellier, France.
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pubmed:publicationType |
Journal Article
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