Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-1-7
pubmed:abstractText
Forty patients with chronic cholecystitis or cholelithiasis were prospectively randomized for therapy with either ciprofloxacin or fleroxacin to study the penetration of these two agents into gallbladder tissue, plasma, and bile. Patients received a 3-day course of ciprofloxacin (500 mg twice a day) or fleroxacin (400 mg once daily) and were subdivided into four groups reflecting intraoperative sample collection at 4, 7, 14, and 25 to 26 h following the last quinolone dose. Mean concentrations in plasma for ciprofloxacin and fleroxacin at 4 and 25 to 26 h postdose were 2.5 and 10 micrograms/ml and 0.3 and 1.8 micrograms/ml, respectively. The concentrations of ciprofloxacin and fleroxacin in bile and gallbladder wall tissue at 25 to 26 h postdose were 4.5 and 8.6 micrograms/ml and 1.2 and 4.4 micrograms/ml, respectively. Both agents demonstrate rapid tissue penetration with persistence at levels appropriate for treatment of biliary pathogens.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8851613-1622179, http://linkedlifedata.com/resource/pubmed/commentcorrection/8851613-2849604, http://linkedlifedata.com/resource/pubmed/commentcorrection/8851613-2939796, http://linkedlifedata.com/resource/pubmed/commentcorrection/8851613-3144536, http://linkedlifedata.com/resource/pubmed/commentcorrection/8851613-3162901, http://linkedlifedata.com/resource/pubmed/commentcorrection/8851613-3292209, http://linkedlifedata.com/resource/pubmed/commentcorrection/8851613-3300537, http://linkedlifedata.com/resource/pubmed/commentcorrection/8851613-3481327, http://linkedlifedata.com/resource/pubmed/commentcorrection/8851613-3582488, http://linkedlifedata.com/resource/pubmed/commentcorrection/8851613-4719580, http://linkedlifedata.com/resource/pubmed/commentcorrection/8851613-6594505, http://linkedlifedata.com/resource/pubmed/commentcorrection/8851613-827989
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
787-91
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Penetration of ciprofloxacin and fleroxacin into biliary tract.
pubmed:affiliation
Department of Surgery, Medical College of Wisconsin, Milwaukee 53226, USA. edmiston@post.its.mcw.edu
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't