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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1997-1-7
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pubmed:abstractText |
1. Levodropropizine (LVDP) is an effective antitussive drug. Its effects on single-unit discharge of vagal afferent C-fibres were tested in anaesthetized cats to assess whether an inhibition of vagal C-fibres is involved in its antitussive properties. Vagal C-fibres, identified by their response to phenylbiguanide (PBG), were recorded via suction electrodes from the distal part of the cut vagus. Based on their response to lung inflation, C-fibres were classified as pulmonary (19 fibres) or non-pulmonary (6 fibres). 2. PBG increased the discharge rate of both C-fibre types and activated a respiratory reflex causing apnoea. This reflex was abolished when the second vagus nerve was cut as well, while PBG-mediated stimulation of the C-fibres was not affected by vagotomy. 3. LVDP was administered intravenously and the C-fibre response to PBG was compared with that before administration of the drug. LVDP reduced both the duration of apnoea and the response of the C-fibre to PBG. 4. Comparison of the C-fibre responses to PBG and to a mixture of PBG and LVDP revealed that the period of apnoea was shortened and the discharge rate of the C-fibre reduced when LVDP was present. 5. The LVDP-induced inhibition of the C-fibre response to PBG was on average 50% in pulmonary and 25% in non-pulmonary fibres. 6. These results suggest that LVDP significantly reduces the response of vagal C-fibres to chemical stimuli. It is, thus, likely that the antitussive effect of LVDP is mediated through its inhibitory action on C-fibres.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8851501-13131246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8851501-1489123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8851501-1604060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8851501-1611233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8851501-2361906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8851501-2461967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8851501-3053580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8851501-3196407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8851501-3196408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8851501-3236245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8851501-3776651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8851501-582141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8851501-6164015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8851501-6188055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8851501-6695127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8851501-7504629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8851501-7683266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8851501-8210758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8851501-952583
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
853-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1996
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pubmed:articleTitle |
Effects of levodropropizine on vagal afferent C-fibres in the cat.
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pubmed:affiliation |
Institut für Physiologie, Ruhr-Universität Bochum, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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