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pubmed-article:8850651pubmed:abstractTextThe presence of specific phenotypes of intraepithelial lymphocytes (IEL) was determined in healthy and diseased gingiva by immunohistochemistry. The cutaneous lymphocyte antigen (CLA) and the alpha IEL beta 7 integrin were detected with the HECA-452 and with the HML-1 monoclonal antibodies, respectively. Some 24-62% of CD3-positive intraepithelial lymphocytes expressed the CLA antigen in the junctional epithelium, while 49-54% expressed the alpha IEL beta 7 integrin. Similar results were obtained in the other gingival epithelia. The fraction of CLA-positive T cells and alpha IEL beta 7 integrin-positive T cells was significantly higher in the gingival epithelia than in the underlying connective tissue, indicating that the T-cell subsets defined by these surface adhesion molecules were selectively localized in the epithelial compartment. Comparison of the fractions of CLA-positive and alpha IEL beta 7 integrin-positive T cells across different disease groups did not show significant differences. The data indicate that intraepithelial lymphocytes expressing the CLA and the alpha IEL beta 7 phenotype are a quantitatively important component of gingival intraepithelial immunity. These adhesion molecules may play a part in the retention of specific T-cell subsets in gingival epithelia.lld:pubmed
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pubmed-article:8850651pubmed:dateRevised2010-11-18lld:pubmed
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pubmed-article:8850651pubmed:articleTitleExpression of the cutaneous lymphocyte antigen and the alpha IEL beta 7 integrin by intraepithelial lymphocytes in healthy and diseased human gingiva.lld:pubmed
pubmed-article:8850651pubmed:affiliationDepartment of Periodontology and Fixed Prosthodontics, University of Bern, Switzerland.lld:pubmed
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pubmed-article:8850651pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:8850651pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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