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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
1997-1-7
|
| pubmed:abstractText |
The presence of specific phenotypes of intraepithelial lymphocytes (IEL) was determined in healthy and diseased gingiva by immunohistochemistry. The cutaneous lymphocyte antigen (CLA) and the alpha IEL beta 7 integrin were detected with the HECA-452 and with the HML-1 monoclonal antibodies, respectively. Some 24-62% of CD3-positive intraepithelial lymphocytes expressed the CLA antigen in the junctional epithelium, while 49-54% expressed the alpha IEL beta 7 integrin. Similar results were obtained in the other gingival epithelia. The fraction of CLA-positive T cells and alpha IEL beta 7 integrin-positive T cells was significantly higher in the gingival epithelia than in the underlying connective tissue, indicating that the T-cell subsets defined by these surface adhesion molecules were selectively localized in the epithelial compartment. Comparison of the fractions of CLA-positive and alpha IEL beta 7 integrin-positive T cells across different disease groups did not show significant differences. The data indicate that intraepithelial lymphocytes expressing the CLA and the alpha IEL beta 7 phenotype are a quantitatively important component of gingival intraepithelial immunity. These adhesion molecules may play a part in the retention of specific T-cell subsets in gingival epithelia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
D
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/CTAGE1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Dental Implants,
http://linkedlifedata.com/resource/pubmed/chemical/Integrins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lymphocyte Homing,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0003-9969
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1125-32
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:8850651-Adult,
pubmed-meshheading:8850651-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:8850651-Antigens, Neoplasm,
pubmed-meshheading:8850651-Connective Tissue,
pubmed-meshheading:8850651-Dental Implants,
pubmed-meshheading:8850651-Epithelium,
pubmed-meshheading:8850651-Gene Expression Regulation,
pubmed-meshheading:8850651-Gingiva,
pubmed-meshheading:8850651-Gingivitis,
pubmed-meshheading:8850651-Humans,
pubmed-meshheading:8850651-Integrins,
pubmed-meshheading:8850651-Membrane Glycoproteins,
pubmed-meshheading:8850651-Periodontitis,
pubmed-meshheading:8850651-Phenotype,
pubmed-meshheading:8850651-Psoriasis,
pubmed-meshheading:8850651-Receptors, Lymphocyte Homing,
pubmed-meshheading:8850651-T-Lymphocyte Subsets,
pubmed-meshheading:8850651-T-Lymphocytes,
pubmed-meshheading:8850651-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:8850651-Tumor Markers, Biological
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Expression of the cutaneous lymphocyte antigen and the alpha IEL beta 7 integrin by intraepithelial lymphocytes in healthy and diseased human gingiva.
|
| pubmed:affiliation |
Department of Periodontology and Fixed Prosthodontics, University of Bern, Switzerland.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|