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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1996-12-10
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pubmed:abstractText |
The dissociation constant (KD) of [3H]phorbol 12,13-dibutyrate (PDBu) binding to protein kinase C (PKC) in membranes of rat cortex and midbrain was significantly decreased with no change in the receptor density (Bmax) following 7-d treatment with a kappa-opioid agonist, U-50,488 (20 mg/kg/d, i.p.). Neither the Bmax nor KD values in pons/medulla were altered by repeated U-50,488 treatment. These results suggest that repeated administration of a kappa-opioid agonist increases the affinity for PDBu binding to the membrane-bound PKC in rat cortex and midbrain, but not in pons/medulla.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0918-6158
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
303-4
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8850328-3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benz...,
pubmed-meshheading:8850328-Animals,
pubmed-meshheading:8850328-Brain,
pubmed-meshheading:8850328-Male,
pubmed-meshheading:8850328-Phorbol 12,13-Dibutyrate,
pubmed-meshheading:8850328-Protein Kinase C,
pubmed-meshheading:8850328-Pyrrolidines,
pubmed-meshheading:8850328-Rats,
pubmed-meshheading:8850328-Rats, Sprague-Dawley,
pubmed-meshheading:8850328-Receptors, Opioid, kappa
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pubmed:year |
1996
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pubmed:articleTitle |
Effects of repeated administration of a kappa-opioid agonist on phorbol ester binding to membrane-bound protein kinase C in rat brain.
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pubmed:affiliation |
Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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