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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1996-10-21
|
| pubmed:abstractText |
We have performed combined chemotherapy with 5-FU, a biochemical modulator, and low dose CDDP for advanced or recurrent cancer of the digestive system. The therapy was effective in 37% of all cases and in 45.5% and 41.6% of esophageal and gastric cancer cases, respectively. In addition, few patients developed adverse side effects including renal disorders, one of the major side effects of CDDP. Therefore, we considered home anti-cancer chemotherapy feasible. For 27 outpatients with advanced cancer of the digestive system including 15 cases of esophageal cancer, 4 cases of gastric cancer, 3 cases of colon cancer, 4 cases of pancreatic cancer and 1 case of gall bladder cancer, 4 to 6 week home adjuvant chemotherapy was performed. The regimen comprised 1 week of oral administration of 300 mg/body/day of UFT-E granules and 5 days of continuous intravenous infusion of 25 mg/body/day of CDDP using an infusor pump. During the follow-up, 3 cases of catheter obstruction, 3 cases of catheter sepsis and 1 case of pneumothorax appeared. These complications all resulted from the catheter, and safe home anti-cancer chemotherapy could be continued because 5-FU and CDDP did not cause severe side effects.
|
| pubmed:language |
jpn
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0385-0684
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
22 Suppl 4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
433-8
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:8849289-Administration, Oral,
pubmed-meshheading:8849289-Ambulatory Care,
pubmed-meshheading:8849289-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:8849289-Chemotherapy, Adjuvant,
pubmed-meshheading:8849289-Cisplatin,
pubmed-meshheading:8849289-Digestive System Neoplasms,
pubmed-meshheading:8849289-Drug Administration Schedule,
pubmed-meshheading:8849289-Female,
pubmed-meshheading:8849289-Fluorouracil,
pubmed-meshheading:8849289-Home Care Services, Hospital-Based,
pubmed-meshheading:8849289-Humans,
pubmed-meshheading:8849289-Infusion Pumps,
pubmed-meshheading:8849289-Infusions, Intravenous,
pubmed-meshheading:8849289-Male,
pubmed-meshheading:8849289-Neoplasm Recurrence, Local,
pubmed-meshheading:8849289-Quality of Life,
pubmed-meshheading:8849289-Tegafur,
pubmed-meshheading:8849289-Uracil
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
[Combined chemotherapy with 5-FU and low dose CDDP for advanced or recurrent cancer of the digestive system and home anti-cancer chemotherapy].
|
| pubmed:affiliation |
1st. Dept. of Surgery, Kansai Medical University.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
English Abstract
|