Linked Life Data

8848271

Source:http://linkedlifedata.com/resource/pubmed/id/8848271

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-10-21
pubmed:abstractText
Apolipoprotein E (ApoE) phenotypes and corresponding allele frequencies were examined in 72 patients (50-90 years of age) with sporadic Alzheimer's disease (AD) and 83 elderly controls (61-96 years of age) in Hokkaido, the northern part of Japan. The frequency of the ApoE-epsilon 4 allele was significantly higher in the patients with either early-onset (age < 65 years) AD (0.40) or late-onset AD (0.26) than in controls (0.07), while the patients developing AD before 50 years of age had no epsilon 4 allele. The mean age at onset of AD was significantly lower in the ApoE-epsilon 4 homozygotes compared to that in the patients with either one or no epsilon 4 allele (60.2, 71.3 and 70.3 years, respectively). Our results indicate that the ApoE-epsilon 4 allele is associated with susceptibility to Japanese sporadic AD developing after 50 years of age and homozygosity for the epsilon 4 allele shifts the onset to earlier age.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
206
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-20
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Apolipoprotein E polymorphism and susceptibility to early- and late-onset sporadic Alzheimer's disease in Hokkaido, the northern part of Japan.
pubmed:affiliation
Department of Psychiatry and Neurology, Asahikawa Medical College, Japan. nuno@asahikawa-med.ac.jp
pubmed:publicationType
Journal Article, Clinical Trial