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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1996-10-24
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pubmed:abstractText |
A dopaminergic neuronal cell line was established which stably expressed human Bcl-2 (MN9D/Bcl-2) or a control vector (MN9D/Neo). Overexpression of Bcl-2 cells led to robust neurite formation without cessation of cell division. Most markers of neuronal and/or dopaminergic maturation were unchanged although the synaptosomal associated protein, SNAP-25, was increased three-fold in MN9D/Bcl-2 cell lines. These data support a role for Bcl-2 in developmental processes at least during a certain stage(s) of neurogenesis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0304-3940
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
202
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
161-4
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8848256-Animals,
pubmed-meshheading:8848256-Blotting, Western,
pubmed-meshheading:8848256-Brain Neoplasms,
pubmed-meshheading:8848256-Cell Line,
pubmed-meshheading:8848256-Dopamine,
pubmed-meshheading:8848256-Humans,
pubmed-meshheading:8848256-Mice,
pubmed-meshheading:8848256-Neurites,
pubmed-meshheading:8848256-Neuroblastoma,
pubmed-meshheading:8848256-Neurons,
pubmed-meshheading:8848256-Proto-Oncogene Proteins,
pubmed-meshheading:8848256-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:8848256-Transfection,
pubmed-meshheading:8848256-Tumor Cells, Cultured,
pubmed-meshheading:8848256-Tyrosine 3-Monooxygenase
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pubmed:year |
1996
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pubmed:articleTitle |
Overexpression of Bcl-2 in a murine dopaminergic neuronal cell line leads to neurite outgrowth.
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pubmed:affiliation |
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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