Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1996-10-22
|
| pubmed:databankReference | |
| pubmed:abstractText |
A complementary DNA clone encoding molluscan insulin-related peptide VII was identified from a complementary DNA library of the cerebral ganglia of the CNS of the freshwater snail, Lymnaea stagnalis. The novel molluscan insulin-related peptide VII complementary DNA encodes a preprohormone resembling the organization of preproinsulin, with a putative signal sequence, and an A and B chain, and is connected by an unusual long C peptide. The A and B chains, as well as the C peptide of molluscan insulin-related peptide VII, differ remarkably in primary structure with the previously identified molluscan insulin-related peptides. The C peptide of molluscan insulin-related peptide VII shares no significant sequence identity with counterparts in other molluscan insulin-related peptides. Both molluscan insulin-related peptide VII and the other molluscan insulin-related peptides exhibit structural features which make them a unique class of the insulin superfamily. Molluscan insulin-related peptide VII complementary DNA was shown to hybridize in situ with messenger RNA present in the cerebral light green cells, neuroendocrine cells that control growth and that have previously been shown to produce molluscan insulin-related peptides I-III and V. Uniquely, the molluscan insulin-related peptide VII gene is also expressed in neurons that may form part of the feeding circuitry in Lymnaea, indicating that it may function as a neurotransmitter/neuromodulator.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0306-4522
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
70
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
589-96
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8848162-Amino Acid Sequence,
pubmed-meshheading:8848162-Animals,
pubmed-meshheading:8848162-Blotting, Northern,
pubmed-meshheading:8848162-Cloning, Molecular,
pubmed-meshheading:8848162-In Situ Hybridization,
pubmed-meshheading:8848162-Lymnaea,
pubmed-meshheading:8848162-Molecular Sequence Data,
pubmed-meshheading:8848162-Neuropeptides,
pubmed-meshheading:8848162-Peptides,
pubmed-meshheading:8848162-RNA, Messenger
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Expression and characterization of molluscan insulin-related peptide VII from the mollusc Lymnaea stagnalis.
|
| pubmed:affiliation |
Department of Experimental Zoology, Vrije Universiteit, Amsterdam, Netherlands.
|
| pubmed:publicationType |
Journal Article
|