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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1996-10-21
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pubmed:abstractText |
Amino acid residues 81-100 of the hepatitis C virus (HCV) nucleoprotein contain a cytotoxic T cell epitope that is recognized by cytotoxic T lymphocytes (CTLs) in association with human leukocyte antigen B44. With panels of truncated and overlapping peptides, the minimal and optimal epitope recognized by CTLs was shown to be a 9-mer peptide (residues 88-96). The peptide can stimulate effectively CTLs that are able to recognize endogenously synthesized and processed HCV nucleoprotein.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1317
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76 ( Pt 12)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3189-93
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:8847528-Amino Acid Sequence,
pubmed-meshheading:8847528-Epitopes, T-Lymphocyte,
pubmed-meshheading:8847528-HLA-B Antigens,
pubmed-meshheading:8847528-HLA-B44 Antigen,
pubmed-meshheading:8847528-Hepacivirus,
pubmed-meshheading:8847528-Hepatitis C,
pubmed-meshheading:8847528-Hepatitis C Antigens,
pubmed-meshheading:8847528-Humans,
pubmed-meshheading:8847528-Lymphocyte Activation,
pubmed-meshheading:8847528-Molecular Sequence Data,
pubmed-meshheading:8847528-Nucleoproteins,
pubmed-meshheading:8847528-Oligopeptides,
pubmed-meshheading:8847528-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:8847528-Viral Core Proteins
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pubmed:year |
1995
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pubmed:articleTitle |
A minimal and optimal cytotoxic T cell epitope within hepatitis C virus nucleoprotein.
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pubmed:affiliation |
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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