Linked Life Data

8846803

Source:http://linkedlifedata.com/resource/pubmed/id/8846803

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1996-10-23
pubmed:abstractText
Experiments have shown that calcium antagonists can prevent restenosis after coronary angioplasty. The first controlled clinical trials, however, failed to show such a benefit after PCTA: the recurrence rate was not significantly influenced by either nifedipine (10 mg q.i.d.) or diltiazem (90 mg t.i.d.). Another trial used a higher dose of diltiazem (mean 329 mg per day) in a larger number of patients, but again the result was negative. In contrast, diltiazem 180 mg per day was reported more recently to significantly reduce restenosis, and high-dose verapamil treatment was similarly successful in a subgroup of patients with stable angina pectoris at the time of primary successful PCTA. Despite some important limitations of the five monocentre trials, the combined analysis of the results shows that calcium antagonists have a beneficial effect on restenosis rate after PTCA. Whether this effect is limited to heart rate slowing substances and to special subgroups of lesions has to be clarified by further studies in sufficiently large patient populations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0195-668X
pubmed:author
pubmed:issnType
Print
pubmed:volume
16 Suppl H
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9-12
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
The effects of calcium antagonists after PTCA.
pubmed:affiliation
Compass-Reha-Centrum, Rehabilitationseinrichtung für Herz-Kreislauf- und Gefässerkrankungen, Kiel, Germany.
pubmed:publicationType
Journal Article, Review