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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
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|
pubmed:dateCreated |
1996-10-23
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|
pubmed:abstractText |
Human adrenomedullin (hADM) is a newly isolated peptide with hypotensive activity in normotensive rats. The objective of this study was to investigate the effect of hADM(13-52) on hypertensive animals. hADM(13-52) induced a dose-dependent decrease in the blood pressure of spontaneously hypertensive rats and renal hypertensive rats. This result suggests that hADM is a novel antihypertensive peptide. In isolated rat aortic arteries, hADM(13-52) produced nitric oxide dependent relaxation and inhibited endothelin 1 and angiotensin II release. These in vitro effects may represent the molecular mechanisms underlying the hypotensive action of hADM in vivo.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0008-4212
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
73
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
N
|
|
pubmed:pagination |
1065-9
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|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:8846402-Adrenomedullin,
pubmed-meshheading:8846402-Angiotensin II,
pubmed-meshheading:8846402-Animals,
pubmed-meshheading:8846402-Antihypertensive Agents,
pubmed-meshheading:8846402-Blood Pressure,
pubmed-meshheading:8846402-Endothelins,
pubmed-meshheading:8846402-Humans,
pubmed-meshheading:8846402-Hypertension,
pubmed-meshheading:8846402-Male,
pubmed-meshheading:8846402-Nitric Oxide,
pubmed-meshheading:8846402-Peptide Fragments,
pubmed-meshheading:8846402-Rats,
pubmed-meshheading:8846402-Rats, Inbred SHR,
pubmed-meshheading:8846402-Rats, Inbred WKY,
pubmed-meshheading:8846402-Rats, Wistar,
pubmed-meshheading:8846402-Vasodilator Agents
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|
pubmed:year |
1995
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|
pubmed:articleTitle |
Vasodilator effect of human adrenomedullin(13-52) on hypertensive rats.
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|
pubmed:affiliation |
J.K. Chang Peptide Research Laboratory, Beijing Medical University, People's Republic of China.
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pubmed:publicationType |
Journal Article,
In Vitro
|
