rdf:type |
|
lifeskim:mentions |
umls-concept:C0019704,
umls-concept:C0025260,
umls-concept:C0039195,
umls-concept:C0042960,
umls-concept:C0205160,
umls-concept:C0276199,
umls-concept:C0871261,
umls-concept:C1414406,
umls-concept:C1511253,
umls-concept:C1549078,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1997894,
umls-concept:C2911692
|
pubmed:issue |
4
|
pubmed:dateCreated |
1996-11-7
|
pubmed:abstractText |
A vaccine against human immunodeficiency virus (HIV) should induce virus-specific cytotoxic T lymphocyte (CTL) activity. Immunization of uninfected volunteers with a canarypox virus expressing HIV envelope was carried out in a phase I trial. Two injections of canarypox expressing HIV-1MN gp 160 (months 0 and 1) were followed by two boosts of recombinant envelope protein (months 3 and 6). HIV envelope-specific CTL were detected in peripheral blood mononuclear cells stimulated with autologous HIV-1-infected blast cells. T cell lines were obtained from 18 of 20 donors: CTL were detected at least once following immunization in 7 (39%) of these 18. This activity was mediated by major histocompatibility complex class I-restricted CD3+CD8+ T cells. For two subjects, this activity was still present 2 years after the initial immunization. The CTL responses with this prime-boost regimen are the best observed with any HIV vaccine tested in humans.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0022-1899
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
174
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
734-8
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8843210-AIDS Vaccines,
pubmed-meshheading:8843210-Antigens, CD3,
pubmed-meshheading:8843210-Antigens, CD8,
pubmed-meshheading:8843210-Avipoxvirus,
pubmed-meshheading:8843210-Female,
pubmed-meshheading:8843210-HIV Envelope Protein gp160,
pubmed-meshheading:8843210-HIV Seronegativity,
pubmed-meshheading:8843210-HIV-1,
pubmed-meshheading:8843210-Histocompatibility Antigens Class I,
pubmed-meshheading:8843210-Humans,
pubmed-meshheading:8843210-Immunization,
pubmed-meshheading:8843210-Immunization, Secondary,
pubmed-meshheading:8843210-Immunologic Memory,
pubmed-meshheading:8843210-Male,
pubmed-meshheading:8843210-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:8843210-Vaccines, Synthetic
|
pubmed:year |
1996
|
pubmed:articleTitle |
Memory cytotoxic T lymphocyte responses in human immunodeficiency virus type 1 (HIV-1)-negative volunteers immunized with a recombinant canarypox expressing gp 160 of HIV-1 and boosted with a recombinant gp160.
|
pubmed:affiliation |
Unité de Virologie et Immunologie Cellulaire, Institut Pasteur, Paris, France.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|