Linked Life Data

8843074

Source:http://linkedlifedata.com/resource/pubmed/id/8843074

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-1-6
pubmed:abstractText
A radioiodinated analogue of neuropeptide FF, [125I][D. Tyr1,(NMe) Phe3]neuropeptide FF, was used as a selective probe to label neuropeptide FF receptors in the rat spinal cord. Following neonatal capsaicin treatment, dorsal rhizotomy or sciatic nerve section, the distribution and possible alterations of spinal cord specific [125I][D.Tyr1,(NMe)Phe3]neuropeptide FF binding sites were evaluated using in vitro quantitative receptor autoradiography. In normal rats, the highest densities of sites were observed in the superficial layers of the dorsal horn (laminae I-II) whereas moderate to low amounts of labelling were seen in the deeper (III-VI) laminae, around the central canal, and in the ventral horn. Capsaicin-treated rats showed a bilateral decrease (47%) in [125I][D.Tyr1,(NMe)Phe3]neuropeptide FF binding in all spinal areas. Unilateral sciatic nerve section and unilateral dorsal rhizotomy induced significant depletions (15-27%) in [125I][D.Tyr1,(NMe)Phe3]neuropeptide FF labelling in the ipsilateral dorsal horn. These results suggest that a proportion of neuropeptide FF receptors is located on primary afferent terminals of the dorsal horn and could thus play a role in the modulation of nociceptive transmission.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Presence of neuropeptide FF receptors on primary afferent fibres of the rat spinal cord.
pubmed:affiliation
Laboratoire de Pharmacologie et de Toxicologie Fondamentales, C.N.R.S., Toulouse, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't