Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1997-1-8
|
| pubmed:abstractText |
1. The aim of the present study was to analyse the noradrenergic transmission in the tail artery of hypertensive rats transgenic for the mouse renin gene Ren-2 (TGR) in comparison with its control, the Sprague-Dawley (SD) rat. 2. Electrical field stimulation (EFS) of vascular segments produced frequency-dependent vasoconstrictions that were significantly greater in TGR arteries. 3. These contractions were abolished by tetrodotoxin (0.1 microM). Phentolamine (50 nM) and prazosin (1 - 10 nM) produced an inhibition of these responses that was significantly greater in SD arteries, whereas that produced by yohimbine (0.5-1 microM) was higher in TGR arteries. In both strains, propranolol (1 microM) potentiated the responses to EFS, and this increase was observed at lower frequencies in TGR arteries. 4. The EFS-evoked [3H]-noradrenaline (NA) release was significantly greater in TGR than in SD rats. However, NA (10 nM-10 microM) reduced and yohimbine and phentolamine (10 nM-10 microM) increased the tritium outflow to a similar degree in both strains. 5. Exogenous NA also induced greater vasoconstriction in TGR arteries. 6. These results suggest the existence in TGR tail artery of an increase in: (a) NA-release and alpha 2-adrenoceptor-mediated contractions, which could contribute to the elevated blood pressure in these rats; and (b) beta-adrenoceptor-mediated vasodilatations, which may be a mechanism to counteract high blood pressure.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Phentolamine,
http://linkedlifedata.com/resource/pubmed/chemical/Prazosin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta,
http://linkedlifedata.com/resource/pubmed/chemical/Renin,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrodotoxin,
http://linkedlifedata.com/resource/pubmed/chemical/Yohimbine
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0144-1795
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
69-77
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8842867-Animals,
pubmed-meshheading:8842867-Animals, Genetically Modified,
pubmed-meshheading:8842867-Arteries,
pubmed-meshheading:8842867-Electric Stimulation,
pubmed-meshheading:8842867-Hypertension,
pubmed-meshheading:8842867-Male,
pubmed-meshheading:8842867-Mice,
pubmed-meshheading:8842867-Norepinephrine,
pubmed-meshheading:8842867-Phentolamine,
pubmed-meshheading:8842867-Prazosin,
pubmed-meshheading:8842867-Rats,
pubmed-meshheading:8842867-Rats, Sprague-Dawley,
pubmed-meshheading:8842867-Receptors, Adrenergic, alpha-2,
pubmed-meshheading:8842867-Receptors, Adrenergic, beta,
pubmed-meshheading:8842867-Renin,
pubmed-meshheading:8842867-Synaptic Transmission,
pubmed-meshheading:8842867-Tetrodotoxin,
pubmed-meshheading:8842867-Vasoconstriction,
pubmed-meshheading:8842867-Yohimbine
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Noradrenergic transmission in the tail artery of hypertensive rats transgenic for the mouse renin gene Ren-2.
|
| pubmed:affiliation |
Departamento de Farmacología y Terapeutica, Facultad de Medicina, Universidad Autónoma, Madrid, Spain.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|