| pubmed-article:8841629 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8841629 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:8841629 | lifeskim:mentions | umls-concept:C0966504 | lld:lifeskim |
| pubmed-article:8841629 | pubmed:issue | 34 | lld:pubmed |
| pubmed-article:8841629 | pubmed:dateCreated | 1996-12-18 | lld:pubmed |
| pubmed-article:8841629 | pubmed:abstractText | The rate of cleavage of a 13-mer substrate by an all-RNA ribozyme with 2 10-mer hybridising arms (TAT RA), appears to be limited by a conformational change involving the longer than necessary arms. The same limitation does not apply to a similar ribozyme with DNA arms (TAT RB) or to an all-RNA ribozyme with only 6 hybridising bases on each arm (TAT RA 6x2). The limitation does not arise in the hybridisation step nor in the dissociation of products. An extra step involving a conformational change of the pre-formed ribozyme-substrate prior to cleavage is introduced to explain the observed kinetics. | lld:pubmed |
| pubmed-article:8841629 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8841629 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8841629 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8841629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8841629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8841629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8841629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8841629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8841629 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8841629 | pubmed:issn | 0261-3166 | lld:pubmed |
| pubmed-article:8841629 | pubmed:author | pubmed-author:LockettT JTJ | lld:pubmed |
| pubmed-article:8841629 | pubmed:author | pubmed-author:HendryPP | lld:pubmed |
| pubmed-article:8841629 | pubmed:author | pubmed-author:McCallM JMJ | lld:pubmed |
| pubmed-article:8841629 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8841629 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8841629 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8841629 | pubmed:pagination | 217-8 | lld:pubmed |
| pubmed-article:8841629 | pubmed:dateRevised | 2000-12-18 | lld:pubmed |
| pubmed-article:8841629 | pubmed:meshHeading | pubmed-meshheading:8841629-... | lld:pubmed |
| pubmed-article:8841629 | pubmed:meshHeading | pubmed-meshheading:8841629-... | lld:pubmed |
| pubmed-article:8841629 | pubmed:meshHeading | pubmed-meshheading:8841629-... | lld:pubmed |
| pubmed-article:8841629 | pubmed:meshHeading | pubmed-meshheading:8841629-... | lld:pubmed |
| pubmed-article:8841629 | pubmed:meshHeading | pubmed-meshheading:8841629-... | lld:pubmed |
| pubmed-article:8841629 | pubmed:meshHeading | pubmed-meshheading:8841629-... | lld:pubmed |
| pubmed-article:8841629 | pubmed:meshHeading | pubmed-meshheading:8841629-... | lld:pubmed |
| pubmed-article:8841629 | pubmed:meshHeading | pubmed-meshheading:8841629-... | lld:pubmed |
| pubmed-article:8841629 | pubmed:meshHeading | pubmed-meshheading:8841629-... | lld:pubmed |
| pubmed-article:8841629 | pubmed:meshHeading | pubmed-meshheading:8841629-... | lld:pubmed |
| pubmed-article:8841629 | pubmed:meshHeading | pubmed-meshheading:8841629-... | lld:pubmed |
| pubmed-article:8841629 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8841629 | pubmed:articleTitle | The mechanism of the hammerhead ribozyme. | lld:pubmed |
| pubmed-article:8841629 | pubmed:affiliation | CSIRO, Division of Biomolecular Engineering, North Ryde, NSW, Australia. | lld:pubmed |
| pubmed-article:8841629 | pubmed:publicationType | Journal Article | lld:pubmed |
