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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1997-2-4
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pubmed:abstractText |
T lymphocytes have been reported to be the predominant inflammatory cells in the liver of patients with chronic viral hepatitis. Their presence may reflect either nonspecific inflammation or a virus-specific immune response. To assess the repertoire of intra-hepatic T cells, we investigated the TCR V beta gene usage of T cells in 10 patients with chronic hepatitis B and 15 with chronic hepatitis C. Liver-derived lymphocytes and peripheral blood lymphocytes were analyzed by flow cytometry. Five out of the 10 hepatitis B patients were found to have an accumulation of certain V beta T cells in the liver (V beta 6.7; V beta 6.7; V beta 3.1, V beta 5.1, and V beta 6.7; V beta 3.1; V beta 12.1, respectively). Four out of the 15 hepatitis C patients were found to have an accumulation of certain V beta T cells in the liver (V beta 5.1; V beta 8 and V beta 5.2 and 5.3; V beta 3.1 and V beta 5.2 and 5.3; V beta 3.1 and V beta 12.1, respectively). Despite a limited screening of V beta subfamilies, this study indicates that, in patients with chronic hepatitis B and C, T cells using a certain V beta gene may accumulate in the liver. This suggests that intra-hepatic T cells are oligoclonal and possibly virus specific. Our results argue against the role of a superantigen in perpetuating liver disease. In addition, this study supports a role for T lymphocytes in the pathogenesis of chronic hepatitis C.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0198-8859
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
56-63
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8839776-Adult,
pubmed-meshheading:8839776-Chronic Disease,
pubmed-meshheading:8839776-Female,
pubmed-meshheading:8839776-Gene Expression,
pubmed-meshheading:8839776-Gene Frequency,
pubmed-meshheading:8839776-Hepatitis B,
pubmed-meshheading:8839776-Hepatitis C,
pubmed-meshheading:8839776-Humans,
pubmed-meshheading:8839776-Liver,
pubmed-meshheading:8839776-Male,
pubmed-meshheading:8839776-Middle Aged,
pubmed-meshheading:8839776-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:8839776-T-Lymphocytes
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pubmed:year |
1996
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pubmed:articleTitle |
Restriction of V beta gene usage of liver-derived lymphocytes in chronic hepatitis B and C.
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pubmed:affiliation |
Service d'Hématologie et Immunologie, Hôpital Beaujon, Clichy, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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